Stability of Diazepam Enema Extemporaneous Formulation in Manzoni Base

Lopalco, Antonio; Lopedota, Angela; Aurelio, Fiorenza; la, Forgia Flavia; Fontana, Sergio; Franco, Massimo; Denora, Nunzio

Abstract

Stability of Diazepam Enema Extemporaneous Formulation in Manzoni Base

Author(s): Lopalco Antonio, Lopedota Angela, Aurelio Fiorenza, la Forgia Flavia, Fontana Sergio, Franco Massimo, Denora Nunzio

Issue: Sep/Oct 2021 - Volume 25, Number 5

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Page(s): 427-430

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Abstract

The authors provide a report on the preparation of an extemporaneous liquid formulation of diazepam enema using an alcohol-free base solution for use by both pediatric and adult patients. A solubility study using this base and the chemical stability of the drug in this formulation was performed by using a high-pressure liquid chromatography analytical method. Results of this study showed that the intrinsic solubility of the drug in this liquid base was 6.03 mg/mL ± 0.06 mg/mL and that diazepam was chemically stable when the formulation was stored at 25°C over a period of 3 months.

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