Abstract

Stability of Diazepam Enema Extemporaneous Formulation in Manzoni Base

Author(s): Lopalco Antonio, Lopedota Angela, Aurelio Fiorenza, la Forgia Flavia, Fontana Sergio, Franco Massimo, Denora Nunzio

Issue: Sep/Oct 2021 - Volume 25, Number 5

Page(s): 427-430

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  • Stability of Diazepam Enema Extemporaneous Formulation in Manzoni Base Page 1
  • Stability of Diazepam Enema Extemporaneous Formulation in Manzoni Base Page 2
  • Stability of Diazepam Enema Extemporaneous Formulation in Manzoni Base Page 3
  • Stability of Diazepam Enema Extemporaneous Formulation in Manzoni Base Page 4

Abstract

The authors provide a report on the preparation of an extemporaneous liquid formulation of diazepam enema using an alcohol-free base solution for use by both pediatric and adult patients. A solubility study using this base and the chemical stability of the drug in this formulation was performed by using a high-pressure liquid chromatography analytical method. Results of this study showed that the intrinsic solubility of the drug in this liquid base was 6.03 mg/mL ± 0.06 mg/mL and that diazepam was chemically stable when the formulation was stored at 25°C over a period of 3 months.

Related Keywords

  • diazepam
  • enema
  • rectal administration
  • benzodiazepine
  • anxiety disorders
  • sedative
  • muscle spasms
  • alcohol withdrawal
  • Manzoni base
  • chemical stability
  • alcohol free
  • epilepsy
  • seizure disorders
  • solubility
  • children

Related Categories

  • PEER-REVIEWED
  • STABILITIES, COMPATIBILITIES
  • DOSAGE FORMS/DRUG CARRIERS
  • MUSCULOSKELETAL DISORDERS
  • NEUROLOGY

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