Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents

Gupta, Vishnu D

Abstract

Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents

Author(s): Gupta Vishnu D

Issue: May/Jun 2007 - Pain Management

View All Articles in Issue

Page(s): 259-261

Download in electronic PDF format for $75

Abstract

The chemical stability of hydrocortisone in an oral liquid dosage form without suspending agents was studied by using a stability-indicating high-performance liquid chromatographic assay method that was developed in our laboratory. The concentrations of the drug (range tested, 12 to 22 µg/mL) were related directly to peak heights, and the percent relative standard deviation based on five injections was 0.8. The products of decomposition and excipients present in the dosage forms did not interfere with the developed assay method. The developed dosage form was almost uniform, with an intraday percent relative standard deviation based on five injections of 2.5, and the 5-day interday percent relative standard deviation was 2.8. The mixture was stable for at least 60 days when stored in amber-colored glass bottles at room temperature. The pH value of the mixture remained constant at 4.6 after 60 days of storage, and the physical appearance of the formulation did not change during the study period.

Related Keywords

Related Categories

Printer-Friendly Version

Related Articles from IJPC

Issue/Page View/Buy	Title/Author (Click for Abstract / Details / Purchase)
May/Jun 2007 Pg. 259-261	Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents Author(s): Gupta Vishnu D
Sep/Oct 2014 Pg. 427-431	Physicochemical and Microbiological Stabilities of Hydrocortisone in InOrpha Suspending Agent Studied Under Various Condition Author(s): Bourget Philippe, Amin Alexandre, Vidal Fabrice, Pieyre Manon, Dosso El Ourmar, Beauvais Raphaelle, Loeuillet Richard
Sep/Oct 2015 Pg. 428-431	Stability of Levothyroxine, Doxycycline, Hydrocortisone, and Pravastatin in Liquid Dosage Forms Stored at Two Temperatures Author(s): Nahata Milap C
Jul/Aug 2008 Pg. 372-374	Chemical Stability of Perphenazine in Two Commercially Available Vehicles for Oral Liquid Dosage Forms Author(s): Gupta Vishnu D
Nov/Dec 2005 Pg. 484-486	Chemical Stability of Perphenazine in Oral Liquid Dosage Forms Author(s): Gupta Vishnu D
Jul/Aug 2001 Pg. 310-312	Wetting and/or Solubilizing Agents, Featured Excipient: Author(s): Allen Loyd V Jr
Mar/Apr 2005 Pg. 165-166	Chemical Stability of Isoniazid in an Oral Liquid Dosage Form Author(s): Gupta Vishnu D, Sood Arun
Sep/Oct 2009 Pg. 445-446	Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms Author(s): Gupta Vishnu D
Sep/Oct 2003 Pg. 386-388	Stability of Oral Liquid Dosage Forms of Glycopyrrolate Prepared with the Use of Powder Author(s): Gupta Vishnu D
Jan/Feb 2011 Pg. 78-80	Chemical Stability of Brompheniramine Maleate in an Oral Liquid Dosage Form Author(s): Gupta Vishnu D, Gupta Vikas S
Sep/Oct 2021 Pg. 431-439	Physicochemical and Microbiological Stability of Extemporaneously Compounded Hydrocortisone Oral Suspensions in PCCA Base, SuspendIt Author(s): Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
Sep/Oct 2010 Pg. 430-435	Quality Control and Physical and Chemical Stability of Hydrocortisone Oral Suspension: An Interlaboratory Study Author(s): Santoveña A, Llabrés M, Fariña JB
Jan/Feb 2010 Pg. 76-77	Chemical Stability of Hydrocortisone in Humco Simple Syrup and Ora-Sweet Vehicle Author(s): Gupta Vishnu D
Jul/Aug 2007 Pg. 347-348	Chemical Stability of Cyproheptadine Hydrochloride in an Oral Liquid Dosage Form Author(s): Gupta Vishnu D
Jul/Aug 2022 Pg. 342-351	Physicochemical and Microbiological Stability of Amitriptyline Hydrochloride Oral Liquid Dosage Forms in PCCA Base, SuspendIt Author(s): Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
Jan/Feb 2018 Pg. 66-75	Stability of an Alcohol-free, Dye-free Hydrocortisone (2 mg/mL) Compounded Oral Suspension Author(s): Manchanda Arushi, Laracy Melissa, Savji Taslim, Bogner Robin H
Jul/Aug 2020 Pg. 315	Hydrocortisone Hemisuccinate 2 mg/mL or Hydrocortisone Sodium Phosphate 2 mg/mL in SyrSpend SF pH4 Author(s): Allen Loyd V Jr
Mar/Apr 2016 Pg. 164-166	Long-term Stability of Zonisamide, Amitriptyline, and Glycopyrrolate in Extemporaneously Prepared Liquid-dosage Forms at Two Temperatures Author(s): Nahata Milap C
Nov/Dec 2018 Pg. 495	Hydrocortisone 2 mg/mL in Inorpha Suspension Author(s): Allen Loyd V Jr
Jul/Aug 2017 Pg. 322-329	Physical and Chemical Stability of Budesonide Mucoadhesive Oral Suspensions (MucoLox) Author(s): Ip Kendice, Carvalho Maria, Shan Ashley, Banov Daniel