Abstract

Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents

Author(s): Gupta Vishnu D

Issue: May/Jun 2007 - Pain Management

Page(s): 259-261

Download in electronic PDF format for $75
  • Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents Page 1
  • Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents Page 2
  • Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents Page 3

Abstract

The chemical stability of hydrocortisone in an oral liquid dosage form without suspending agents was studied by using a stability-indicating high-performance liquid chromatographic assay method that was developed in our laboratory. The concentrations of the drug (range tested, 12 to 22 µg/mL) were related directly to peak heights, and the percent relative standard deviation based on five injections was 0.8. The products of decomposition and excipients present in the dosage forms did not interfere with the developed assay method. The developed dosage form was almost uniform, with an intraday percent relative standard deviation based on five injections of 2.5, and the 5-day interday percent relative standard deviation was 2.8. The mixture was stable for at least 60 days when stored in amber-colored glass bottles at room temperature. The pH value of the mixture remained constant at 4.6 after 60 days of storage, and the physical appearance of the formulation did not change during the study period.

Related Keywords

  • hydrocortisone
  • corticosteroid
  • glucocorticoid
  • steroid
  • stability
  • liquid formulations

Related Categories

  • PEER-REVIEWED
  • STABILITIES, COMPATIBILITIES
  • ALLERGY/IMMUNOLOGY/INFLAMMATION

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
May/Jun 2007
Pg. 259-261
Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents
Author(s): Gupta Vishnu D
Sep/Oct 2014
Pg. 427-431
Physicochemical and Microbiological Stabilities of Hydrocortisone in InOrpha Suspending Agent Studied Under Various Condition
Author(s): Bourget Philippe, Amin Alexandre, Vidal Fabrice, Pieyre Manon, Dosso El Ourmar, Beauvais Raphaelle, Loeuillet Richard
Sep/Oct 2015
Pg. 428-431
Stability of Levothyroxine, Doxycycline, Hydrocortisone, and Pravastatin in Liquid Dosage Forms Stored at Two Temperatures
Author(s): Nahata Milap C
Jul/Aug 2008
Pg. 372-374
Chemical Stability of Perphenazine in Two Commercially Available Vehicles for Oral Liquid Dosage Forms
Author(s): Gupta Vishnu D
Nov/Dec 2005
Pg. 484-486
Chemical Stability of Perphenazine in Oral Liquid Dosage Forms
Author(s): Gupta Vishnu D
Jul/Aug 2001
Pg. 310-312
Wetting and/or Solubilizing Agents, Featured Excipient:
Author(s): Allen Loyd V Jr
Mar/Apr 2005
Pg. 165-166
Chemical Stability of Isoniazid in an Oral Liquid Dosage Form
Author(s): Gupta Vishnu D, Sood Arun
Sep/Oct 2009
Pg. 445-446
Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms
Author(s): Gupta Vishnu D
Sep/Oct 2003
Pg. 386-388
Stability of Oral Liquid Dosage Forms of Glycopyrrolate Prepared with the Use of Powder
Author(s): Gupta Vishnu D
Jan/Feb 2011
Pg. 78-80
Chemical Stability of Brompheniramine Maleate in an Oral Liquid Dosage Form
Author(s): Gupta Vishnu D, Gupta Vikas S
Sep/Oct 2021
Pg. 431-439
Physicochemical and Microbiological Stability of Extemporaneously Compounded Hydrocortisone Oral Suspensions in PCCA Base, SuspendIt
Author(s): Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
Sep/Oct 2010
Pg. 430-435
Quality Control and Physical and Chemical Stability of Hydrocortisone Oral Suspension: An Interlaboratory Study
Author(s): Santoveña A, Llabrés M, Fariña JB
Jan/Feb 2010
Pg. 76-77
Chemical Stability of Hydrocortisone in Humco Simple Syrup and Ora-Sweet Vehicle
Author(s): Gupta Vishnu D
Jul/Aug 2007
Pg. 347-348
Chemical Stability of Cyproheptadine Hydrochloride in an Oral Liquid Dosage Form
Author(s): Gupta Vishnu D
Jul/Aug 2022
Pg. 342-351
Physicochemical and Microbiological Stability of Amitriptyline Hydrochloride Oral Liquid Dosage Forms in PCCA Base, SuspendIt
Author(s): Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
Jan/Feb 2018
Pg. 66-75
Stability of an Alcohol-free, Dye-free Hydrocortisone (2 mg/mL) Compounded Oral Suspension
Author(s): Manchanda Arushi, Laracy Melissa, Savji Taslim, Bogner Robin H
Jul/Aug 2020
Pg. 315
Hydrocortisone Hemisuccinate 2 mg/mL or Hydrocortisone Sodium Phosphate 2 mg/mL in SyrSpend SF pH4
Author(s): Allen Loyd V Jr
Mar/Apr 2016
Pg. 164-166
Long-term Stability of Zonisamide, Amitriptyline, and Glycopyrrolate in Extemporaneously Prepared Liquid-dosage Forms at Two Temperatures
Author(s): Nahata Milap C
Nov/Dec 2018
Pg. 495
Hydrocortisone 2 mg/mL in Inorpha Suspension
Author(s): Allen Loyd V Jr
Jul/Aug 2017
Pg. 322-329
Physical and Chemical Stability of Budesonide Mucoadhesive Oral Suspensions (MucoLox)
Author(s): Ip Kendice, Carvalho Maria, Shan Ashley, Banov Daniel