Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Measuring Testosterone Biomarkers in Serum and Saliva: Are They Accurate?

Author(s):  Tan Robert S

Issue:  Nov/Dec 2004 - Endotoxin
View All Articles in Issue

Page(s):  419-423

Measuring Testosterone Biomarkers in Serum and Saliva: Are They Accurate? Page 1
Measuring Testosterone Biomarkers in Serum and Saliva: Are They Accurate? Page 2
Measuring Testosterone Biomarkers in Serum and Saliva: Are They Accurate? Page 3
Measuring Testosterone Biomarkers in Serum and Saliva: Are They Accurate? Page 4
Measuring Testosterone Biomarkers in Serum and Saliva: Are They Accurate? Page 5

Download in electronic PDF format for $75

Abstract:  Clinicians are confronted daily with patients whose symptoms suggest low levels of sex hormones such as testosterone. Testosterone deficiency may result from a variety of conditions from pituitary tumor to age-related decline in testosterone production (andropause). Diagnosis of low testosterone may be complicated by obesity, depression, diabetes and other chronic diseases, certain medications, and other factors. A range of both serum and saliva tests are available to test testosterone levels, but the best laboratory method for confirming testosterone deficiency is controversial. The results of saliva testing, if performed correctly, have been shown to correlate well with those of serum testing. Despite its greater comfort and convenience and lower cost, however, saliva testing has not yet been accepted into mainstream medicine. Measuring testosterone level is complicated by the fact that hormone release is cyclical and is influenced by many factors, including stress, age, and time of day. Which test result(s) best represents a patient’s true testosterone status has not been resolved. Furthermore, research has shown that sex hormone levels do not correlate well with symptoms. The clinician should rely on both clinical assessment and laboratory data to identify the “normal” testosterone level for each individual, using a concept the author describes as “relative hypogonadism” to determine which patients require testosterone supplementation.

Related Keywords: Robert S. Tan, MD, MBA, AGSF, testosterone, hormone levels, andropause, androgen status, saliva testing, serum testing, hypogonadism, hormone deficiency, men

Related Categories: HRT

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Measuring Testosterone Biomarkers in Serum and Saliva: Are They Accurate?
Tan Robert S
Nov/Dec 2004
Pg. 419-423

Using Serum Hormone Analysis to Develop Hormone Replacement Therapy Regimens - Part 2
Ford Gina
, Garcia Lea
Jan/Feb 2001
Pg. 52-54

Saliva Tests, Part 2: Salivary Hormones, Hormone Replacement Pharmacokinetics, and the Importance of Timely Testing
Kells John
, Dollbaum Charles M
Sep/Oct 2009
Pg. 392-399

Saliva Tests, Part 1: Clinical Use, Elements of Testing, and Guidelines for Posttreatment Interpretation
Kells John
, Dollbaum Charles M
Jul/Aug 2009
Pg. 280-288

Using Serum Hormone Analysis to Develop Hormone Replacement Therapy Regimens-Part 1
Ford Gina
, Garcia Lea
Nov/Dec 2000
Pg. 421-422

Testosterone Levels in an Aging Population: Screen, Measure, and Restore
Kells John
, DollbaumCharles M
Mar/Apr 2011
Pg. 102-112

The Value of Hormone Assessment
Collins Joseph J
Sep/Oct 2001
Pg. 342-344

Testosterone Deficiency in Men: New Treatments for Andropause
Biundo Bruce
, Shippen Eugene
Nov/Dec 2000
Pg. 429-431

Andropause: New Perspectives
Biundo Bruce
May/Jun 2004
Pg. 175-178

Hormone Treatment Options for Males: What to Do for Men with Low Testosterone
Biundo Bruce
Jul/Aug 2009
Pg. 276-279

Hormone Treatment Options for Males: What to do for Men with Low Testosterone
Biundo Bruce
Jan/Feb 2024
Pg. 28-32

Testosterone Replacement Therapy for Female Androgen Insufficiency Syndrome
Tan Robert S
Jul/Aug 2005
Pg. 259-264

View Sample
Protocol of Blood Serum Eye Drops
Katsakoulas Ioannis
, Lougovoi Claudia, Paraskevopoulou Penelope, Vougioukas Nikolaos
May/Jun 2015
Pg. 252-260

Subcutaneous Testosterone Anastrozole Therapy in Men: Rationale, Dosing, and Levels on Therapy
Glaser Rebecca L
, York Anne E
Jul/Aug 2019
Pg. 325-339

Androgen Deficiency in Women: Understanding the Science, Controversy and Art of Treating Our Patients - Part 1
Cutter Christopher B
Jan/Feb 2004
Pg. 16-21

Hormone Therapy: It's Time for a Second Opinion
Collins Joseph J
, Ahlgrimm Maria
Mar/Apr 2008
Pg. 122-127

Quality Control Analytical Methods: End-preparation Assessments and Tests for Compounded Sterile Preparations
McElhiney Linda F
Jul/Aug 2013
Pg. 307-311

The Salivary Hormone Profile in the Clinical Evaluation of Women
Stephenson Kenna
Nov/Dec 2004
Pg. 427-435

The Science Behind Hormone Replacement Therapy, Part 1
Wepfer Scott T
Nov/Dec 2001
Pg. 462-464

Low Testosterone in Older Men: A Discussion and Review of Literature on Health Consequences of Hypogonadism in the Aging Male
Biundo Bruce
Nov/Dec 2009
Pg. 494-496

Return to Top