Stability of Glycopyrrolate Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Author(s): Storms Meredith L, Stewart James T, Warren Flynn W
Issue: Jan/Feb 2003 - Terrorism
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Page(s): 65-67
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Abstract: The stability of 0.2-mg/mL glycopyrrolate injection in 6-mL
polypropylene syringes stored at ambient temperature and
at 4ºC for up to 90 days was investigated. A high-performance
liquid chromatographic stability-indicating assay was
used to determine the concentration level of glycopyrrolate
injection 0, 1, 4, 7, 15, 30, 45, 60, and 90 days after preparation
of the syringes. Benzyl alcohol, which was added as a
preservative, did not interfere with the assay. The injection
in plastic syringes was stable for up to 90 days at both ambient
temperature and at 4ºC. The pH of the glycopyrrolate injection
did not change appreciably during the 90-day study
period. These data indicate the stability of glycopyrrolate
injection under the storage conditions investigated in this
study.
Related Keywords:
Glycopyrrolate injection, stability of
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