Abstract

Contamination Control in Compounding Areas

Author(s): Mulder Kyle, Gonzales Ben A

Issue: Jul/Aug 2019 - Volume 23, Number 4

Page(s): 271-278

Download in electronic PDF format for $75
  • Contamination Control in Compounding Areas Page 1
  • Contamination Control in Compounding Areas Page 2
  • Contamination Control in Compounding Areas Page 3
  • Contamination Control in Compounding Areas Page 4
  • Contamination Control in Compounding Areas Page 5
  • Contamination Control in Compounding Areas Page 6
  • Contamination Control in Compounding Areas Page 7
  • Contamination Control in Compounding Areas Page 8

Abstract

In pharmaceutical compounding, effective contamination control is based on a complete understanding of the impact, sources, mechanisms, and prevention of adulterants in the compounding suite. Only then do the multiple facets of designing, constructing, maintaining, cleaning, using, and monitoring controlled environments make sense. This article presents an overview of the types of contaminants likely to compromise the potency and for their eradication. The information provided also applies to the contamination of other sites such as surgery suites, hallways, bathrooms, and the home setting. In a series of upcoming articles, the importance of compounding techniques, primary and secondary engineering controls, personal protective equipment, environmental monitoring, cleaning processes, hazardous-drug considerations, and certification of the compounding suite will be discussed in detail.

Related Keywords

  • Kyle Mulder, NSF, CETA RCCP-SCF, NEBB CPT CP
  • drug contamination prevention
  • contaminants
  • adulterants
  • environmental controls
  • compounded sterile preparations
  • drug safety
  • drug purity
  • hazardous drugs
  • heat
  • humidity
  • weather
  • water
  • light
  • sound
  • vibration
  • static electricity
  • chemical contaminants
  • physical contaminants
  • environmental contaminants
  • vapors
  • air quality
  • gases
  • airflow
  • particulates
  • decontamination
  • air filtration
  • air filters
  • insanitary conditions
  • ISO Class 5 area
  • personnel
  • staff training

Related Categories

  • ENVIRONMENTAL
  • QUALITY CONTROL
  • HAZARDOUS DRUGS

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
Jul/Aug 2019
Pg. 271-278
Contamination Control in Compounding Areas
Author(s): Mulder Kyle, Gonzales Ben A
Jan/Feb 2020
Pg. 30-36
Quality Control: Personal Protective Equipment for Use When Handling Hazardous Drugs
Author(s): Dillon L R
May/Jun 2021
Pg. 211-216
Quality Control: Testing for "Micromonsters": Viable Air and Surface Sampling in Aseptic Compounding
Author(s): Mulder Kyle
Sep/Oct 2018
Pg. 369-384
Certification of Powder-containment Hoods for Nonsterile Compounding
Author(s): Mulder Kyle, Dozzi Raphael
Nov/Dec 2006
Pg. 446-448
Basics of Compounding for Hazardous Drugs, Part 2: Regulation and Sources of Contamination
Author(s): Allen Loyd V Jr
Sep/Oct 2022
Pg. 411-418
Sterile Basics of Compounding: Contamination Control Strategies, Part 1
Author(s): Summers Amy
Sep/Oct 2018
Pg. 387-398
Compounding Enclosures: Ensuring Safety During the Preparation of Sterile and Nonsterile Formulations
Author(s): Ashe Krystina, Baskett Dustin
Jan/Feb 2020
Pg. 7-12
Primary Engineering Controls in Pharmaceutical Compounding, Part 2: Biosafety Cabinets
Author(s): Mulder Kyle
Nov/Dec 2019
Pg. 447-452
Primary Engineering Controls in Pharmaceutical Compounding, Part 1: Unidirectional-airflow Workstations, Compounding Aseptic Isolators, and Compounding Aseptic Containment Isolators
Author(s): Mulder Kyle
Nov/Dec 2011
Pg. 526-527
PostScription: Drug Disposal: Compounding Pharmacists' Involvement in the Prevention of Prescription Drug Misuse and Abuse
Author(s): Williams LaVonn A
Nov/Dec 2022
Pg. 497-504
Sterile Basics of Compounding: Contamination Control Strategies, Part 2
Author(s): Summers Amy
Sep/Oct 2017
Pg. 356
PreScription: 2017 Pharmacy Compounding Issues: The U.S. Food and Drug Administration, Harzardous Drugs, and Wasted Drugs
Author(s): Allen Loyd V Jr
Jan/Feb 2021
Pg. 6-12
Cleanroom Cleanliness
Author(s): Mulder Kyle
Jul/Aug 2013
Pg. 307-311
Quality Control Analytical Methods: End-preparation Assessments and Tests for Compounded Sterile Preparations
Author(s): McElhiney Linda F
Jul/Aug 2009
Pg. 300-310
Preparing Nonsterile and Sterile Hazardous Compounds in an Institutional Setting
Author(s): McElhiney Linda F
Mar/Apr 2007
Pg. 149-151
Basics of Compounding for Hazardous Drugs, Part 4: Developing the Hazardous Drugs List and Containment Workstations
Author(s): Allen Loyd V Jr
May/Jun 2015
Pg. 232-238
Basics of Sterile Compounding: Contamination Control
Author(s): Akers Michael J
Jul/Aug 2018
Pg. 345-349
Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags
Author(s): Breukels Oscar, van der Gronde Toon, Simons-Sanders Kathleen, Crul Mirjam
Mar/Apr 2021
Pg. 131-139
Intravenous Admixture Preparation Considerations, Part 9-A: Error Prevention in Intravenous Admixture Preparation
Author(s): Allen Loyd V Jr
Jan/Feb 2022
Pg. 72-79
Evaluation of Closed-system Transfer Devices in Reducing Potential Risk for Surface Contamination Following Simulated Hazardous-drug Preparation and Compounding (Reprint)
Author(s): Soefje Scott, Rickabaugh Keith, Rajkumar Rahul, Wall Kathryn P