Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Containment of Hazardous Particulates in the Compounding Pharmacy

Author(s):  Allen Loyd V Jr

Issue:  Jul/Aug 2003 - After the Women's Health Initiative Trial
View All Articles in Issue

Page(s):  281-285

Containment of Hazardous Particulates in the Compounding Pharmacy Page 1
Containment of Hazardous Particulates in the Compounding Pharmacy Page 2
Containment of Hazardous Particulates in the Compounding Pharmacy Page 3
Containment of Hazardous Particulates in the Compounding Pharmacy Page 4
Containment of Hazardous Particulates in the Compounding Pharmacy Page 5

Download in electronic PDF format for $65

Abstract:  This article describes the experience of Ray Moreno, RPh, FIACP, a compounding pharmacist/pharmacy owner since 1982. When a technician developed a small benign lump in a breast after the pharmacy had begun compounding more bioidentical hormone preparations, he began to look for additional ways to protect his employees. Although gloves were worn during compounding, Moreno became concerned about airborne particulates. He then provided technicians with surgical masks and began investigating fume hoods, which still did not appear to be adequate protection. Next he investigated hood-type air-filtration devices. He invested in a chemo hood and other protective devices but still was not confident they provided enough protection. He evaluated his employees by means of saliva testing to determine staff levels of estrogen, estradiol and testosterone over an 18-month period, with increasing protection for employees during compounding, and was dismayed to find that they had elevated hormone levels. He then contacted Germfree Laboratories, Inc., a Florida company specializing in laminar flow equipment, to develop special equipment. After company experts visited the pharmacy and talked with Moreno, they designed a negative-pressure particulate containment hood that covers the work space and is 2 feet above the work surface. The hood, designed for high-efficiency particulate air filter testing and certification, has the inward face velocity of a class I biological safety cabinet. Everything needed for compounding is contained within the hood. Further refinements of procedures, in addition to use of the hood, resulted in lowering of employee hormone levels to the normal range. Moreno continues to work with the company to design a laminar-flow glovebox for compounding.

Related Keywords: Containment, of hazardous particulates during compounding, Hazards, minimizing during compounding, Safety, during compounding, Toxic substances, minimizing exposure during compounding


Printer-Friendly Version

Related Articles from IJPC
(Click for Abstract / Details / Purchase)
Containment of Hazardous Particulates in the Compounding Pharmacy
Allen Loyd V Jr
Jul/Aug 2003
Pg. 281-285

Compounding in the Pharmacy Curriculum: Beyond the Basics
Hinkle Amanda R
, Newton Gail D
May/Jun 2004
Pg. 181-185

Compounding Enclosures: Ensuring Safety During the Preparation of Sterile and Nonsterile Formulations
Ashe Krystina
, Baskett Dustin
Sep/Oct 2018
Pg. 387-398

Current Topical Treatments in Wound Healing - Part 1
Helmke Christopher D
Jul/Aug 2004
Pg. 269-274

An Ounce of Prevention: Controlling Hazards in Extemporaneous Compounding Practices
Kastango Eric S
, Trissel Lawrence A, Bradshaw Brian D
Sep/Oct 2003
Pg. 401-416

Product Containment in the Compounding Laboratory
Vidrine Eric
May/Jun 2003
Pg. 213-214

PostScription: Guidance to Achieve Accreditation from the Pharmacy Compounding Accreditation Board
Pharmacy Compounding Accreditation Board
Sep/Oct 2010
Pg. 440-441

pH Stability of Injectable Fentanyl, Bupivacaine, or Clonidine Solution or a Ternary Mixture in 0.9% Sodium Chloride in Two Types of Polypropylene Syringes
Jappinen Annaliisa L
, Kokki H, Rasi A S, Naaranlahti Toivo J
Nov/Dec 2002
Pg. 471-474

The Role of Compounding in Closing Therapeutic Gaps--Abstracts from FIP 2013
Lutz Eugene
, Pauletti Giovanni, Carvalho Maria, Davidson Gigi, Ashworth Lisa, Subramaniam Vaiyapuri, LlambĂ­ Francesc
Jan/Feb 2014
Pg. 6-12

Basics of Compounding for Cold Sores or Fever Blisters
Allen Loyd V Jr
May/Jun 2004
Pg. 206-209