Abstract

Estrogen in the Treatment and Prevention of Alzheimer's Disease

Author(s): Paganini-Hill Annlia, Henderson Victor W

Issue: Jan/Feb 1998 - Hormone Replacement

Page(s): 24-29

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Abstract

Accumulating evidence suggests that, for women, estrogen replacement therapy may be beneficial in both treating and preventing Alzheimer’s disease. In this article, the authors discuss estrogen in the treatment and prevention of Alzheimer’s disease and the effect of estrogen on the brain. Tables present information relating to studies of estrogen replacement therapy in the treatment of Alzheimer’s disease and effects of various routes of administration, effects of formulations of estrogen on Alzheimer’s disease risk and effects of estrogen on the brain. Figures show epidemiologic studies, relative risks and 95% confidence intervals for estrogen replacement therapy and Alzheimer’s disease, and dose and duration effect for estrogen replacement therapy and Alzheimer’s disease. The authors conclude that, in clinical trials, although they have been small and generally not randomized, estrogen appears to improve several symptoms of Alzheimer’s disease in some women. However, little information is available to determine the optimum formulation or administration route of the estrogen compound.

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