Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection

Gupta, Vishnu D; Bailey, RE

A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

LEARN MORE

Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection

Author(s): Gupta Vishnu D, Bailey RE

Issue: Jan/Feb 2000 - Compounding for Pain Management
View All Articles in Issue

Page(s): 66-68

Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection Page 1

Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection Page 2

Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection Page 3

Download in electronic PDF format for $75

Abstract: A high-performance liquid chromatographic assay method for the quantitation of alatrofloxacin in intravenous (IV) admixtures has been developed. The method is accurate and precise, with a percent relative standard deviation of 1.2% based on five injections. The method is stability indicating since the product of decomposition, trovafloxacin, did not interfere with the assay procedure. The IV admixtures of alatrofloxacin (1.88 mg/mL) in 5% dextrose and 0.45% sodium-chloride injections were stable for at least nine days when stored at room temperature. The pH values of the admixtures did not change and they remained clear throughout this study.

Related Keywords: alatrofloxacin, dextrose, high performance liquid chromatography, injection, IV admixtures, pH, sodium chloride, stability, trovafloxacin

Related Categories: INFUSION, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version

Title/Author (Click for Abstract / Details / Purchase)	Issue/Page View/Buy
Related Articles from IJPC
Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection Gupta Vishnu D, Bailey RE	Jan/Feb 2000 Pg. 66-68
Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Zhang Yan-ping, Trissel Lawrence A	Mar/Apr 1997 Pg. 132-134
Stability of Cefepime Hydrochloride Dextrose in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Gupta Vishnu D, Maswoswe J, Bailey RE	Nov/Dec 1997 Pg. 435-436
Compatibility and Stability of Potassium Chloride and Magnesium Sulfate in 0.9% Sodium Chloride Injection and 5% Dextrose Injection Solutions Quay Irene, Tan Edward	Jul/Aug 2001 Pg. 323-324
Stability of Cefmetazole Sodium in 5% dextrose Injection and 0.9% Sodium Chloride Injection Gupta Vishnu D, Maswoswe J, Bailey RE	May/Jun 1997 Pg. 208-209
Stability of Ketorolac Tromethamine in 5% Dextrose Injection and 0.9% Sodium Chloride Injections Gupta Vishnu D, Maswoswe J, Bailey RE	May/Jun 1997 Pg. 206-207
Stability of Milrinone Lactate 200 mcg/mL in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Wong Frances, Gill Mark A	Mar/Apr 1998 Pg. 168-169
Quantitation of Testosterone-Cypionate-in-Oil Injection using High Performance Liquid Chromatography Gupta Vishnu D, Pramar Y	Jul/Aug 1999 Pg. 314-315
Physical and Chemical Stability of Trepostinil Sodium Injection Packaged in Plastic Syringe Pump Reservoirs. Xu Quanyun A, Trissel Lawrence A, Pham Lien	May/Jun 2004 Pg. 228-230
Stability of an Oral Liquid Dosage Form of Trovafloxacin Mesylate and Its Quantitation in Tablets Using High-Performance Liquid Chromatography Gupta Vishnu D	May/Jun 2000 Pg. 233-235
Quantitation of Testosterone Propionate in an Injection Using High Performance Liquid Chromatography Gupta Vishnu D	Mar/Apr 1999 Pg. 158-159
Drug Compatibility and Stability in Dextrose vs Saline Newton David W	May/Jun 2011 Pg. 190-192
Dextrose 20% and Sodium Chloride 20% Sclerosing Injection Allen Loyd V Jr	Jul/Aug 1999 Pg. 299
Stability of Dexmedetomidine in Polyvinyl Chloride Bags Containing 0.9% Sodium Chloride Intended for Subcutaneous Infusions Wolfe Amanda, Zhang Jeremy, Lapenskie Julie, Downar James, Kanji Salmaan	Jul/Aug 2021 Pg. 330-335
Quality-Control Analytical Methods: High-Performance Liquid Chromatography Kupiec Thomas C	May/Jun 2004 Pg. 223-227
Stability of Succinylcholine Chloride Injection at Ambient Temperature and 4 Degree C in Polypropylene Syringes Storms Meredith L, Stewart James T, Warren Flynn W	Jan/Feb 2003 Pg. 68-70
Stability of Tubocurarine Chloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes Stewart James T, Storms Meredith L, Warren Flynn W	Jul/Aug 2002 Pg. 308-310
Effect of Freezing, Long-Term Storage, and Microwave Thawing on the Stability of Cefepime in 5% Dextrose Infusion Polyvinyl Chloride Bags Schlesser Vincent, Hecq Jean-Daniel, Vanbeckbergen Danielle, Jamart Jacques, Galanti Laurence M	Sep/Oct 2002 Pg. 391-394
pH Stability of Injectable Fentanyl, Bupivacaine, or Clonidine Solution or a Ternary Mixture in 0.9% Sodium Chloride in Two Types of Polypropylene Syringes Jappinen Annaliisa L, Kokki H, Rasi A S, Naaranlahti Toivo J	Nov/Dec 2002 Pg. 471-474
Stability of Ampicillin Sodium, Nafcillin Sodium, and Oxacillin Sodium in AutoDose Infusion System Bags Zhang Yanping, Trissel Lawrence A	May/Jun 2002 Pg. 226-229
Return to Top