Stability of Ketamine Hydrochloride Injection After Reconstitution in Water for Injection and Storage in 1-mL Tuberculin Polypropylene Syringes for Pediatric Use
Author(s): Gupta Vishnu D
Issue: Jul/Aug 2002 - Compounding for BHRT and Legal and Regulatory Issues
View All Articles in Issue
Page(s): 316-317
Download in electronic PDF format for $65
Abstract: The stability of ketamine hydrochloride (10 mg/mL) in water for injection stored
in polypropylene syringes has been studied at 25ºC by means of a stability-indicating
high-performance liquid chromatographic assay method. The concentrations
of the drug were directly related to peak heights, and the percent relative standard
deviation based on five injections was 1.9. The drug decomposed only when
the solution was boiled after sodium hydroxide was added. It did not decompose
in the presence of an acid or after 30 minutes of boiling. The injection did not
lose potency after 30 days of storage at 25ºC, and the pH value of 4.2 did not change.
Ketamine hydrochloride appears to be a very stable drug.
Related Keywords:
Ketamine hydrochloride injection, stability of after reconstitution
| Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
Stability of Ketamine Hydrochloride Injection After Reconstitution in Water for Injection and Storage in 1-mL Tuberculin Polypropylene Syringes for Pediatric Use
Gupta Vishnu D
|
Jul/Aug 2002
Pg. 316-317
|
Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Storms Meredith L, Stewart James T, Warren Flynn W
|
Sep/Oct 2002
Pg. 388-390
|
Amitriptyline Hydrochloride 2%, Baclofen 5%, Ketamine Hydrochloride 5%, Ketoprofen 10% in Pluronic Lecithin Organogel
Allen Loyd V Jr
|
Nov/Dec 2010
Pg. 512
|
Ketamine Hydrochloride 5%, Gabapentin 10%, Clonidine Hydrochloride 0.2%, and Baclofen 2% in Lipoderm
Allen Loyd V Jr
|
May/Jun 2016
Pg. 231
|
Chemical Stability of Phenylephrine HCl After Reconstitution in 0.9% Sodium Chloride Injection for Infusion
Gupta Vishnu D
|
Mar/Apr 2004
Pg. 153-155
|
Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection
Zhang Yan-ping, Trissel Lawrence A
|
Mar/Apr 1997
Pg. 132-134
|
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Clonidine Hydrochloride Packaged in Plastic Syringes
Xu Quanyun A, Trissel Lawrence A, Pham Lien
|
Jan/Feb 2002
Pg. 66-69
|
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Bupivacaine Hydrochloride Packaged in Plastic Syringes
Trissel Lawrence A, Xu Quanyun A, Pham Lien
|
Jan/Feb 2002
Pg. 70-73
|
Stability of Cefepime Hydrochloride After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D, Ling Jie
|
Mar/Apr 2001
Pg. 151-152
|
Formulation and Accelerated Stability Studies for an Extemporaneous Suspension of Amiodarone Hydrochloride
Alexander Kenneth S, Thyangarajapuram N
|
Sep/Oct 2003
Pg. 389-393
|
