Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Stability of Venlafaxine Immediate-Release Suspensions

Author(s):  Donnelly Ronald F, Wong Keith, Goddard Rob, Johanson Christel

Issue:  Jan/Feb 2011 - Volume 15, Number 1
View All Articles in Issue

Note:  Electronic version includes errata or revisions.

Abstract:  Venlafaxine is a novel antidepressant that works by inhibiting the reuptake of serotonin and norepinephrine. The objectives of this study were to reformulate a venlafaxine extended-release suspension into an immediate-release preparation and then determine the physical and chemical stability of the new venlafaxine formulation. Suspensions of venlafaxine (75 mg/5mL) were prepared from extended-release microspheres that had been reduced to powder and then dispersed in either OraPlus/OraSweet (50:50) or simple syrup. Triplicate samples of the suspensions were collected from amber plastic bottles stored at either 5ºC or 23ºC on days 0, 7, 14, 21, and 28, and assayed. Physical stability was based on color and pH changes. A validated high-performance liquid chromatography assay method was used to determine the chemical stability of the active ingredient. This study found that venlafaxine immediate-release suspensions, prepared in either OraPlus/OraSweet or simple syrup, are physically and chemically stable for 28 days when stored in amber plastic bottles at either 5ºC or 23ºC.

Related Keywords: Ronald F. Donnelly, MSc (Chem), BSc (Pharm), Keith Wong, BSc (Pharm), Rob Goddard, BSc (Pharm), Christel Johanson, BSc (Pharm), venlafaxine, antidepressant, immediate release suspension, stability, excipients

Related Categories: MENTAL HEALTH, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, NEUROLOGY

Printer-Friendly Version




Download in electronic PDF format for $55

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Stability of Venlafaxine Immediate-Release Suspensions Donnelly Ronald F, Wong Keith, Goddard Rob, Johanson Christel Jan/Feb 2011 81-84 Buy
Formulation, Physical Stability, and the Clinical Effectiveness of Extemporaneous Ivermectin Oral Solution Zaid Abdel-Naser, Zaaror Yara Abu, Qaddumi Aiman, Ratrout Ala, Ahmad Ayda, Hamad Emad, Kittana Naim Nov/Dec 2021 523-527 Buy
Drug-release Assessment of Compounded Topical Nifedipine and Diltiazem in Commonly Used Bases for Wound Healing Teimouri Arezou, Yeung Pollen, Agu Remigius U Nov/Dec 2020 501-508 Buy
Stability Studies of Fludrocortisone Acetate Capsules and Fludrocortisone Acetate Titrated Powders (Powder Triturates) Brandin Thibaut, Wasilewski Maya, Panuccio Camille, Bouguergour Cyrielle, Primas Nicolas, Lamy Edouard, Jean Christophe, Bertault-Peres Pierre, Rathelot Pascal, Curti Christophe, Vanelle Patrice Mar/Apr 2022 150-154 Buy
Stability of Compounded Topical Nifedipine in Cream, Gel, and Ointment Bases Teimouri Arezou, Yeung Pollen, Agu Remigius U Jul/Aug 2021 344-351 Buy
Stability of Compounded Diltiazem Hydrochloride in Cream, Ointment, and Gel Formulations for Topical Use Teimouri Arezou, Yeung Pollen, Agu Remigius U Nov/Dec 2020 482-490 Buy
Stability of Prednisone in Oral Mix Suspending Vehicle Friciu Mihaela, Plourde Kevin, Leclair Grégoire, Danapoulos Panagiota, Savji Taslim Jul/Aug 2015 337-339 Buy
Chemical Stability of Fentanyl in Polypropylene Syringes and Polyvinylchloride Bags Donnelly Ronald F Nov/Dec 2005 482-483 Buy
Stability of Tranexamic Acid Mouth Rinse Donnelly Ronald F Sep/Oct 2018 412-416 Buy
Stability of Fentanyl Citrate in Polyolefin Bags Donnelly Ronald F Nov/Dec 2016 514-516 Buy