Formulation Optimization Study for an Immediate-Release Tablet

Kyriacos, Soula; Dimassi, Hani

Abstract

Formulation Optimization Study for an Immediate-Release Tablet

Author(s): Kyriacos Soula, Dimassi Hani

Issue: May/Jun 2009 - Pain Management

View All Articles in Issue

Page(s): 259-261

Download in electronic PDF format for $75

Abstract

A simple method based on statistical analysis was used to optimize an immediate-release tablet formulation that includes a water-soluble drug. The objective of this study was to optimize different factors to develop a tablet formulation that has good tablet characteristics (hardness of 85 to 90 Newtons), disintegration time between 3 to 6 minutes, and friability <1%. The critical formulation/process factors were the type and concentration of microcrystalline cellulose, the ratio of lactose to microcrystalline cellulose, the concentration of croscarmellose, and the compression force. A two-step approach was implemented. First an optimization study was performed to determine the type of microcrystalline cellulose and its ratio to lactose. Subsequently, a final optimization formulation study was performed based on the results obtained in the preliminary study. Data were analyzed using the SPSS 15 (Statistical Software for Social Sciences). The differences in means between the formulation and the targeted product

Related Keywords

Related Categories

Printer-Friendly Version

Related Articles from IJPC

Issue/Page View/Buy	Title/Author (Click for Abstract / Details / Purchase)
May/Jun 2009 Pg. 259-261	Formulation Optimization Study for an Immediate-Release Tablet Author(s): Kyriacos Soula, Dimassi Hani
Sep/Oct 2021 Pg. 364-371	Filling the Gaps on the Institute for Safe Medication Practices (ISMP) Do Not Crush List for Immediate-release Products Author(s): Uttaro Elizabeth, Zhao Fang, Schweighardt Anne
Jan/Feb 2011 Pg. 81-84	Stability of Venlafaxine Immediate-Release Suspensions Author(s): Donnelly Ronald F, Wong Keith, Goddard Rob, Johanson Christel
Sep/Oct 2017 Pg. 418-425	Kinetic Analysis of Drug Release from Compounded Slow-release Capsules of Liothyronine Sodium (T3) Author(s): Bakhteyar Hamid, Cassone Clayton, Kohan Hamed Gilzad, Sani Shabnam N
Sep/Oct 2001 Pg. 401-405	Release of Morphine Sulfate from Compounded Slow-Release Capsules: The Effect of Formulation on Release Author(s): Bogner Robin H, Szwejkowski Jessica, Houston Alana
Sep/Oct 2023 Pg. 431-439	The Influence of Polymers, Surfactants, and Other Excipients on Naproxen Sodium Release from Matrices Prepared and the Effect of These Additives on the Swelling Rate of the Tablet Author(s): Alhmoud Hassan, Akkam Yazan, Omari Derar, Alghananim Alaa, Melhem Mohammad Bani
Jan/Feb 2013 Pg. 10-22	Compounding Slow-release Capsules: A Comprehensive Review and an Excel Spreadsheet for Faster Calculation of Excipients Author(s): Zur Eyal
Sep/Oct 2019 Pg. 399-402	Sterile Basics: Pharmaceutical Waters Used in Sterile and Nonsterile Compounding Author(s): Allen Loyd V Jr
Mar/Apr 2011 Pg. 175	Erratum: Stability of Venlafaxine Immediate-Release Suspensions Author(s): Allen Loyd V Jr
Sep/Oct 2013 Pg. 424-431	In Vitro Evaluation of Extemporaneously Compounded Immediate-release Capsules with Premixed Excipients, Based on the Biopharmaceutics Classification System (BCS) of the Drugs Author(s): Pinheiro Vanessa A, Danopoulos Panagiota, Demirdjian Lara, Nogueira Rodrigo J L, Dubois Fanny
May/Jun 2003 Pg. 233-239	Formulation Development and Stability Testing of Extemporaneous Suspension Prepared From Dapsone Tablets Author(s): Kaila Nitin, El-Ries Mohamed, Riga A, Alexander Kenneth S, Dollimore D
May/Jun 2011 Pg. 224-232	Quality Control Analytical Methods: Aqua Pura: Water Purification Systems and United States Pharmacopeia Waters for the Compounding Pharmacy, Part 2: USP Waters: Experts at the United States Pharmacopeia Answer Compounders' Questions Author(s): Schnatz Rick, Hernandex-Cardoso Antonio
Nov/Dec 2022 Pg. 516-521	Formulation Development of Modafinil Sprinkle Dosage Form: Study on the Effect of Food on Dosage Author(s): Kumaravelrajan Rajagopal, Karthik B, Venkatasan Suba
Sep/Oct 2024 Pg. 364-372	Crushability Analysis of Immediate-Release Oral Tablets and Capsules from the 2020-22 FDA Novel Drug Approvals Author(s): Saei Kamaladdin, Schweighardt Anne, Zhao Fang
Jan/Feb 2023 Pg. 60-71	Formulation, Evaluation, and Characterization of Ibuprofen Nanocrystals Tablets with Conventional Market Product Author(s): Chauhan Nikita N, Patel Jayvadan K
Mar/Apr 2008 Pg. 163-169	Pharmaceutical Development of Enteric-Release Hard Gelatin Capsules in the Compounding Setting Author(s): de Oliveira Ferreira Anderson, Holandino Carla
Sep/Oct 1999 Pg. 409-411	In Vitro Studies on the Release of Morphine Sulfate from Compounded Slow-Release Morphine-Sulfate Capsules Author(s): Webster Kathy D, Al-Achi Antoine, Greenwood Robert
Jan/Feb 2022 Pg. 80-87	Investigation of the Effects of Excipients in the Compounding of Amlodipine Besylate Orally Disintegrating Tablets Author(s): Azmi Nurual Hanisah Saiful, Ming Long Chiau, Uddin ABM Helal, Sarker Zaidul Islam, Bin Liew Kai
Jul/Aug 2021 Pg. 304-309	Basics of Compounding: Excipients Used in Nonsterile Compounding, Part 10: Rectal Suppository Bases Author(s): Allen Loyd V Jr
Sep/Oct 2017 Pg. 388-392	Basics of Compounding: 3D Printing--Pharmacy Applications: Geometric Shape Effects on 3D Printing Author(s): Allen Loyd V Jr