Transdermal Delivery of Metformin Hydrochloride from a Semisolid Vehicle

Polonini, Hudson; Lopes, Cândido Paulo José; Andrade, Junquiera Laura; Loures, Sharlene; Raposo, Nádia RB; Fernandes, Brandão Marcos Antônio; de, Oliveira Ferreira Anderson

Abstract

Transdermal Delivery of Metformin Hydrochloride from a Semisolid Vehicle

Author(s): Polonini Hudson, Lopes Cândido Paulo José, Andrade Junquiera Laura, Loures Sharlene, Raposo Nádia RB, Fernandes Brandão Marcos Antônio, de Oliveira Ferreira Anderson

Issue: Jan/Feb 2019 - Volume 23, Number 1

View All Articles in Issue

Page(s): 65-69

Download in electronic PDF format for $75

Abstract

Metformin hydrochloride is a traditional, FDA-approved drug used as a first-line drug of choice to treat type 2 diabetes. Research has shown metformin hydrochloride effective in injuries, including age-related maladies. The purpose of this ex vivo study was to evaluate the use of a commercial transdermal vehicle as a semisolid, liposomal vanishing cream (Pentravan) to deliver metformin hydrochloride through the human skin. The experiments were conducted as percutaneous absorption assay in Franz Diffusion Cells, coupled with freshly excised human skin and analyzed by high-performance liquid chromatography. Both methods were based on validated methods of both the United States Pharmacopeial Convention, Inc. and the International Conference on Harmonization. A 46.7% permeation percentage was found, with a drug flux of 3.91 µg cm-2 h-1 and a lag time of 0.51 h, following pseudo first-order absorption kinetics. These results showed that transdermal metformin hydrochloride can be an option for patients searching for diverse clinical effects.

Related Keywords

Related Categories

Printer-Friendly Version

Related Articles from IJPC

Issue/Page View/Buy	Title/Author (Click for Abstract / Details / Purchase)
Mar/Apr 2003 Pg. 106-113	Veterinary Transdermal Medications: A to Z Author(s): Davidson Gigi S
Jan/Feb 2019 Pg. 65-69	Transdermal Delivery of Metformin Hydrochloride from a Semisolid Vehicle Author(s): Polonini Hudson, Lopes Cândido Paulo José, Andrade Junquiera Laura, Loures Sharlene, Raposo Nádia RB, Fernandes Brandão Marcos Antônio, de Oliveira Ferreira Anderson
Mar/Apr 2015 Pg. 152-160	Transdermal Delivery of Nisoldipine: Refinement of Vehicles Author(s): El Maghraby Gamal M, Ahmed Amal A, Osman Mohamed A
May/Jun 2003 Pg. 170-174	Five Compounds for Treating Diabetes-Related Conditions Author(s): Meece Jerry
Jul/Aug 2014 Pg. 332-340	Evaluation of Percutaneous Absorption Performance for Human Female Sexual Steroids into Pentravan Cream Author(s): Polonini Hudson C, Brandão Marcos Antônio F, Ferreira Anderson O, Ramos Cristiano, Raposo Nádia R B
Sep/Oct 2023 Pg. 362-366	Compounding Metformin for Use in Functional Medicine Author(s): Desai Sarina, Thompson Tara
May/Jun 2014 Pg. 256-261	Preparation and In Vitro Evaluation of a Pluronic Lecithin Organogel Containing Ricinoleic Acid for Transdermal Delivery Author(s): Boddu Sai HS, Bonam Sindhu Prabha, Wei Yangjie, Alexander Kenneth
Sep/Oct 2023 Pg. 424-430	Evaluation of Compounded Transdermal Analgesic Formulations Using the Franz Finite Dose Model Author(s): Baneshi Marzieh, Tyagi Deependra, Panneerselvam Ezilrani, MacKenzie Graham, Coleman Johngary, Zhang Shine X
Jul/Aug 2011 Pg. 308-315	Transdermals: The Skin as Part of a Drug Delivery System Author(s): Allen Loyd V Jr
Jan/Feb 2001 Pg. 65-67	Oral Liquid Vehicles, Featured Excipient: Author(s): Allen Loyd V Jr
May/Jun 2016 Pg. 250-256	Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives Author(s): Trimble John, Light Bob
Jan/Feb 2012 Pg. 62-63	The Use of Pluronic Lecithin Organogels in the Transdermal Delivery of Drugs Author(s): Bramwell Bethany L, Williams LaVonn A
Mar/Apr 2007 Pg. 157	Metformin Hydrochloride 100-mg/mL Oral Liquid Author(s): Allen Loyd V Jr
Mar/Apr 2020 Pg. 168-175	Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel Author(s): Dahal Amit, Neupane Rabin, Boddu Sai HS, Renukuntla Jwala, Khupse Rahul, Dudley Richard
Mar/Apr 2015 Pg. 161-166	Skin Permeation and Antinociception of Compounded Topical Cyclobenzaprine Hydrochloride Formulations Author(s): Bryson Evan, Hartman Rachel, Arnold John, Gorman Greg, Sweitzer Sarah.Asbill Scott
Nov/Dec 2017 Pg. 530-535	Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives Author(s): Trimble John O, Light Bob
Nov/Dec 2018 Pg. 466-468	Case Study: Absorption of Testosterone Cream via Scrotal Delivery Author(s): Needham Shawn, Needham Shane
May/Jun 2013 Pg. 247-253	Effect of Formulation pH on Transdermal Penetration of Antiemetics Formulated in Poloxamer Lecithin Organogel Author(s): Woodall Rachel, Arnold John J, McKay Doug, Abill C Scott
Nov/Dec 2012 Pg. 516-523	Rice Bran Oil: Preparation and Evaluation of Novel Liquisolid and Semisolid Formulations Author(s): Ammar Hussein O, Al-Okbi Sahar Y, Mostafa Dina M, Helal Amr M
Nov/Dec 2017 Pg. 446-452	Feline Transdermal Formulation Considerations Author(s): Forsythe Lauren Eichstadt