Abstract

Transdermal Delivery of Metformin Hydrochloride from a Semisolid Vehicle

Author(s): Polonini Hudson, Lopes Cândido Paulo José, Andrade Junquiera Laura, Loures Sharlene, Raposo Nádia RB, Fernandes Brandão Marcos Antônio, de Oliveira Ferreira Anderson

Issue: Jan/Feb 2019 - Volume 23, Number 1

Page(s): 65-69

Download in electronic PDF format for $75
  • Transdermal Delivery of Metformin Hydrochloride from a Semisolid Vehicle Page 1
  • Transdermal Delivery of Metformin Hydrochloride from a Semisolid Vehicle Page 2
  • Transdermal Delivery of Metformin Hydrochloride from a Semisolid Vehicle Page 3
  • Transdermal Delivery of Metformin Hydrochloride from a Semisolid Vehicle Page 4
  • Transdermal Delivery of Metformin Hydrochloride from a Semisolid Vehicle Page 5

Abstract

Metformin hydrochloride is a traditional, FDA-approved drug used as a first-line drug of choice to treat type 2 diabetes. Research has shown metformin hydrochloride effective in injuries, including age-related maladies. The purpose of this ex vivo study was to evaluate the use of a commercial transdermal vehicle as a semisolid, liposomal vanishing cream (Pentravan) to deliver metformin hydrochloride through the human skin. The experiments were conducted as percutaneous absorption assay in Franz Diffusion Cells, coupled with freshly excised human skin and analyzed by high-performance liquid chromatography. Both methods were based on validated methods of both the United States Pharmacopeial Convention, Inc. and the International Conference on Harmonization. A 46.7% permeation percentage was found, with a drug flux of 3.91 µg cm-2 h-1 and a lag time of 0.51 h, following pseudo first-order absorption kinetics. These results showed that transdermal metformin hydrochloride can be an option for patients searching for diverse clinical effects.

Related Keywords

  • formulation
  • metformin
  • type 2 diabetes mellitus
  • topical preparations
  • transdermal delivery
  • percutaneous absorption
  • obesity
  • aging
  • degenerative disorders
  • liposomal vehicle

Related Categories

  • DIABETES
  • EXCIPIENTS
  • FORMULATIONS
  • PEER-REVIEWED
  • DOSAGE FORMS/DRUG CARRIERS
  • ENDOCRINOLOGY/HORMONES/ MENOPAUSE/ANDROPAUSE

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
Mar/Apr 2003
Pg. 106-113
Veterinary Transdermal Medications: A to Z
Author(s): Davidson Gigi S
Jan/Feb 2019
Pg. 65-69
Transdermal Delivery of Metformin Hydrochloride from a Semisolid Vehicle
Author(s): Polonini Hudson, Lopes Cândido Paulo José, Andrade Junquiera Laura, Loures Sharlene, Raposo Nádia RB, Fernandes Brandão Marcos Antônio, de Oliveira Ferreira Anderson
Mar/Apr 2015
Pg. 152-160
Transdermal Delivery of Nisoldipine: Refinement of Vehicles
Author(s): El Maghraby Gamal M, Ahmed Amal A, Osman Mohamed A
May/Jun 2003
Pg. 170-174
Five Compounds for Treating Diabetes-Related Conditions
Author(s): Meece Jerry
Jul/Aug 2014
Pg. 332-340
Evaluation of Percutaneous Absorption Performance for Human Female Sexual Steroids into Pentravan Cream
Author(s): Polonini Hudson C, Brandão Marcos Antônio F, Ferreira Anderson O, Ramos Cristiano, Raposo Nádia R B
Sep/Oct 2023
Pg. 362-366
Compounding Metformin for Use in Functional Medicine
Author(s): Desai Sarina, Thompson Tara
May/Jun 2014
Pg. 256-261
Preparation and In Vitro Evaluation of a Pluronic Lecithin Organogel Containing Ricinoleic Acid for Transdermal Delivery
Author(s): Boddu Sai HS, Bonam Sindhu Prabha, Wei Yangjie, Alexander Kenneth
Sep/Oct 2023
Pg. 424-430
Evaluation of Compounded Transdermal Analgesic Formulations Using the Franz Finite Dose Model
Author(s): Baneshi Marzieh, Tyagi Deependra, Panneerselvam Ezilrani, MacKenzie Graham, Coleman Johngary, Zhang Shine X
May/Jun 2016
Pg. 250-256
Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives
Author(s): Trimble John, Light Bob
Jul/Aug 2011
Pg. 308-315
Transdermals: The Skin as Part of a Drug Delivery System
Author(s): Allen Loyd V Jr
Jan/Feb 2001
Pg. 65-67
Oral Liquid Vehicles, Featured Excipient:
Author(s): Allen Loyd V Jr
Jan/Feb 2012
Pg. 62-63
The Use of Pluronic Lecithin Organogels in the Transdermal Delivery of Drugs
Author(s): Bramwell Bethany L, Williams LaVonn A
Mar/Apr 2007
Pg. 157
Metformin Hydrochloride 100-mg/mL Oral Liquid
Author(s): Allen Loyd V Jr
Mar/Apr 2020
Pg. 168-175
Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel
Author(s): Dahal Amit, Neupane Rabin, Boddu Sai HS, Renukuntla Jwala, Khupse Rahul, Dudley Richard
Mar/Apr 2015
Pg. 161-166
Skin Permeation and Antinociception of Compounded Topical Cyclobenzaprine Hydrochloride Formulations
Author(s): Bryson Evan, Hartman Rachel, Arnold John, Gorman Greg, Sweitzer Sarah.Asbill Scott
Nov/Dec 2017
Pg. 530-535
Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives
Author(s): Trimble John O, Light Bob
Nov/Dec 2018
Pg. 466-468
Case Study: Absorption of Testosterone Cream via Scrotal Delivery
Author(s): Needham Shawn, Needham Shane
May/Jun 2013
Pg. 247-253
Effect of Formulation pH on Transdermal Penetration of Antiemetics Formulated in Poloxamer Lecithin Organogel
Author(s): Woodall Rachel, Arnold John J, McKay Doug, Abill C Scott
Nov/Dec 2012
Pg. 516-523
Rice Bran Oil: Preparation and Evaluation of Novel Liquisolid and Semisolid Formulations
Author(s): Ammar Hussein O, Al-Okbi Sahar Y, Mostafa Dina M, Helal Amr M
Nov/Dec 2017
Pg. 446-452
Feline Transdermal Formulation Considerations
Author(s): Forsythe Lauren Eichstadt