Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Basics of Compounding: Compounding with Silicones

Author(s):  Allen Loyd V Jr

Issue:  May/Jun 2015 - Volume 19, Number 3
View All Articles in Issue

Page(s):  223-230

Note:  Electronic version includes supplemental material.

Basics of Compounding: Compounding with Silicones Page 1
Basics of Compounding: Compounding with Silicones Page 2
Basics of Compounding: Compounding with Silicones Page 3
Basics of Compounding: Compounding with Silicones Page 4
Basics of Compounding: Compounding with Silicones Page 5
Basics of Compounding: Compounding with Silicones Page 6
Basics of Compounding: Compounding with Silicones Page 7
Basics of Compounding: Compounding with Silicones Page 8

Download in electronic PDF format for $75

Abstract:  Since the 1940s, methylchlorosilanes have been used to treat glassware to prevent blood from clotting. The use of silicones in pharmaceutical and medical applications has grown to where today they are used in many lifesaving devices (pacemakers, hydrocephalic shunts) and pharmaceutical applications from tubing, to excipients in topical formulations, to adhesives to affix transdermal drug delivery systems, and are also being used in products as active pharmaceutical ingredients, such as antiflatulents. About 60% of today’s skin-care products now contain some type of silicone where they are considered safe and are known to provide a pleasant “silky touch,” nongreasy, and non-staining feel. Silicones exhibit many useful characteristics, and the safety of these agents supports their numerous applications; their biocompatibility is partially due to their low-chemical reactivity displayed by silicones, low-surface energy, and their hydrophobicity. Silicones are used both as active ingredients and as excipients. In addition is their use for “siliconization,” or surface treatment, of many parenteral packaging components. Dimethicone and silicone oil are used as lubricants on stoppers to aid machineability, in syringes to aid piston movement, or on syringe needles to reduce pain upon injection. Silicones are also useful in pharmaceutical compounding as is discussed in this article. Included with this article are in developing formulations with silicones.

Related Keywords: Loyd V. Allen, Jr., PhD, RPh, methylchlorosilanes, silicones, medical devices, drug delivery equipment, excipients, topical formulations, adhesives, transdermal drug delivery systems, antiflatuence agents, flatulence, skin care products, siliconization, parenteral packaging components, dimethicone, silicone oil, lubricants, physical properties, drug penetration, formulation types

Related Categories: DERMATOLOGY, EXCIPIENTS, PACKAGING, DOSAGE FORMS/DRUG CARRIERS

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Veterinary Transdermal Medications: A to Z
Davidson Gigi S
Mar/Apr 2003
Pg. 106-113

Basics of Compounding: Compounding with Silicones
Allen Loyd V Jr
May/Jun 2015
Pg. 223-230

Transdermals: The Skin as Part of a Drug Delivery System
Allen Loyd V Jr
Jul/Aug 2011
Pg. 308-315

Wetting and/or Solubilizing Agents, Featured Excipient:
Allen Loyd V Jr
Jul/Aug 2001
Pg. 310-312

Rapid-Dissolve Technology: An Interview With Loyd V. Allen, Jr., PhD, RPh
Allen Loyd V Jr
Nov/Dec 2003
Pg. 449-450

Current Topical Treatments in Wound Healing - Part 1
Helmke Christopher D
Jul/Aug 2004
Pg. 269-274

Personalized Medicine and Customized Drug Delivery Systems: The New Trend of Drug Delivery and Disease Management
Soni Abhishek
, Gowthamarajan Kuppusamy, Radhakrishnan Arun
Mar/Apr 2018
Pg. 108-121

Formulation and In Vitro Evaluation of a Ramipril Entrapped in a Microsponge-based Drug-delivery System
Taghi Hassanien Sagban
, Abdulbaqi Mustafa R, Samein Laith Hamza, Rahmani Maha H Philip
Jul/Aug 2023
Pg. 340-346

Basics of Sterile Compounding: Biopharmaceutics of Injectable Dosage Forms
Akers Michael J
Jan/Feb 2017
Pg. 47-56

Quality Control: Personal Protective Equipment for Use When Handling Hazardous Drugs
Dillon L R
Jan/Feb 2020
Pg. 30-36

Basics of Sterile Compounding: Excipients Used in Injections
Akers Michael J
Jul/Aug 2017
Pg. 301-308

Official Water-Repelling Agents: The Official Silicones, Featured Excipient:
Allen Loyd V Jr
May/Jun 2001
Pg. 228

Basics of Compounding–Nonsterile: Compounding Self-emulsifying Drug Delivery Systems and Other Self-emulsifying Lipid Formulations, Part 1
Allen Loyd V Jr
May/Jun 2018
Pg. 220-228

Basics of Compounding--Nonsterile: Compounding Self-emulsifying Drug Delivery Systems and Other Self-emulsifying Lipid Formulations, Part 2
Allen Loyd V Jr
Jul/Aug 2018
Pg. 294-300

Compounding in the Pharmacy Curriculum: Beyond the Basics
Hinkle Amanda R
, Newton Gail D
May/Jun 2004
Pg. 181-185

Basics of Sterile Compounding: Sterile Product Packaging and Delivery Systems
Akers Michael J
Nov/Dec 2015
Pg. 491-500

Advanced Compounding: Compounding with Microneedle Arrays, Part 3: Microneedle Array Development in the Literature and Quality Control of Microneedle Arrays
Allen Loyd V Jr
Jan/Feb 2023
Pg. 30-37

The Use of Pluronic Lecithin Organogels in the Transdermal Delivery of Drugs
Bramwell Bethany L
, Williams LaVonn A
Jan/Feb 2012
Pg. 62-63

Basics of Compounding: Excipients Used in Nonsterile Compounding, Part 11: Drug Tastes: Innate, Induced, and Improved
Allen Loyd V Jr
Sep/Oct 2021
Pg. 396-400

Basics of Compounding: Compounding Nonsterile Preparations Using Cyclodextrins
Allen Loyd V Jr
Mar/Apr 2022
Pg. 118-126

Return to Top