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Basics of Compounding–Nonsterile: Compounding Self-emulsifying Drug Delivery Systems and Other Self-emulsifying Lipid Formulations, Part 1

Author(s):  Allen Loyd V Jr

Issue:  May/Jun 2018 - Volume 22, Number 3
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Page(s):  220-228

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Abstract:  Self-emulsifying Drug Delivery Systems are being introduced and are increasing in popularity for improving the solubility of lipophilic drugs. They are isotropic mixtures of drug, oil, surfactant and/or cosurfactant, and sometimes cosolvents. There is some overlap of this discussion in the March-April 2018 issue of the International Journal of Pharmaceutical Compounding in an article on the discussion of microemulsions. Self-emulsifying Drug Delivery Systems can be orally administered in hard-gelatin capsules so they can be appropriate for compounding after the formulation has been developed. Their primary advantages include enhanced solubility and bioavailability for lipophilic drugs that provide formulation challenges. As will be seen in this 2-part series, there are numerous dosage forms in which Self-emulsifying Drug Delivery Systems can be incorporated.

Related Keywords: Loyd V. Allen, Jr., PhD, RPh, self-emulsifying drug delivery systems, self-emulsifying lipid formulations, lipophilic drugs, solubility, isotropic mixtures, bioavailability, oral formulations, self-emulsifying oil formulations, microemulsions, surfactants, permeability, cosurfactant, oil, cosolvent, absorption, nanoparticle sorbents, capsule filling, solid carriers, encapsulating, tableting, spray drying, melt granulation, melt extrusion, extrusion spheronization

Related Categories: EXCIPIENTS, DOSAGE FORMS/DRUG CARRIERS

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