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Basics of Compounding: Capsules

Author(s):  Allen Loyd V Jr

Issue:  Mar/Apr 2016 - Volume 20, Number 2
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Abstract:  Capsules have been used for administering medications to patients more than a century and have an important role in drug delivery. When a primary care provider prescribes a tablet, the choice is usually, but not always, limited to commercially available products. A capsule, however, can be prepared extemporaneously, which provides dosing flexibility for the primary care provider and the pharmacist. This article discusses the definitions/types of capsules, their applications, composition, preparation, capsule sizes, the encapsulation process, capsule cleaning, physiochemical considerations, quality control in the preparation of capsules, packaging/storage, stability, and patient counseling to determine the proper capsule size. Also, provided are sample formulations.

Related Keywords: Loyd V. Allen, Jr.,PhD,RPh, capsules, drug delivery, sample formulation, dry powder fill, dry powder mixing, encapsulation methods, bulk density, excipients, compatibility, humidity, stability, dose uniformity, storage conditions, patient adherence, swallowing


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