Abstract

Basics of Compounding: Capsules

Author(s): Allen Loyd V Jr

Issue: Mar/Apr 2016 - Volume 20, Number 2

Page(s): 125-134

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Abstract

Capsules have been used for administering medications to patients more than a century and have an important role in drug delivery. When a primary care provider prescribes a tablet, the choice is usually, but not always, limited to commercially available products. A capsule, however, can be prepared extemporaneously, which provides dosing flexibility for the primary care provider and the pharmacist. This article discusses the definitions/types of capsules, their applications, composition, preparation, capsule sizes, the encapsulation process, capsule cleaning, physiochemical considerations, quality control in the preparation of capsules, packaging/storage, stability, and patient counseling to determine the proper capsule size. Also, provided are sample formulations.

Related Keywords

  • capsules
  • drug delivery
  • sample formulation
  • dry powder fill
  • dry powder mixing
  • encapsulation methods
  • bulk density
  • excipients
  • compatibility
  • humidity
  • stability
  • dose uniformity
  • storage conditions
  • patient adherence
  • swallowing

Related Categories

  • EXCIPIENTS
  • FORMULATIONS
  • STABILITIES, COMPATIBILITIES
  • QUALITY CONTROL
  • DOSAGE FORMS/DRUG CARRIERS
  • STORAGE

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