Basics of Compounding: Compounding Films
Author(s): Allen Loyd V Jr
Issue: Jul/Aug 2016 - Volume 20, Number 4
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Page(s): 298-305
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Abstract: Films, which are a dosage form designed to dissolve on contact with a wet surface within a very short time, are thin sheets placed in the oral cavity for dissolution and absorption of the active drug. This dosage form is gaining popularity because of its convenience. Discussed within this article are the applications, advantages/disadvantages, composition, preparation, physicochemical considerations, quality control, packaging/labeling/storage, stability, and formulation considerations as they relate to films. Also provided are example formulations for compounding.
Related Keywords: Loyd V. Allen, Jr., PhD, RPh, oral administration, saliva, fast dissolving films, dissolve on contact, formulations, thin-film vehicle, rapid release, first-pass effect, drug release rate, edible polymers, water-soluble polymers, modified cellulose, edible gums, copolymers, plasticizers, casting, extrusion, active pharmaceutical ingredients, nicardipine hydrochloride, montelukast, 3D printing, children, elderly, swallowing disorders
Related Categories: EXCIPIENTS, FORMULATIONS, STABILITIES, COMPATIBILITIES, QUALITY CONTROL, DOSAGE FORMS/DRUG CARRIERS