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Compounded Orodispersible Films with Natural Ingredients for Halitosis: A Clinical Experience

Author(s):  Apolinário Régis De Souza, Chaves Maria Das Graças Afonso Miranda, Gonçalves Hanny Reis Mockdeci, Martins Isadora Conde Ferreria, De Paula Renée Mazilão, Granato Ana Paula Alves, Polonini Hudson Caetano, Brandão Marcos Antônio Fernandes, Ferreira Anderson De Oliveira, Raposo Nádia Rezende Barbosa

Issue:  Nov/Dec 2018 - Volume 22, Number 6
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Page(s):  512-515

Compounded Orodispersible Films with Natural Ingredients for Halitosis: A Clinical Experience Page 1
Compounded Orodispersible Films with Natural Ingredients for Halitosis: A Clinical Experience Page 2
Compounded Orodispersible Films with Natural Ingredients for Halitosis: A Clinical Experience Page 3
Compounded Orodispersible Films with Natural Ingredients for Halitosis: A Clinical Experience Page 4

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Abstract:  Halitosis can be described as unpleasant odors emanating from the oral cavity. It is usually associated with decomposition action of bacteria present mainly on the back of the tongue and periodontal pockets, and able to produce volatile sulfur compounds. We conducted a study at the Faculty of Dentistry, Federal University of Juiz de Fora and evaluated the therapeutic effect of two natural extracts, Camellia sinensis (green tea) and resveratrol in the form of oral polymer films, to control halitosis. Fifty volunteers (students of health courses) participated in the research after orientation and signing the informed consent form. The anamnesis was made by researchers. The physical examination was made to verify the inclusion criteria. Each participant received 45 polymeric films to be consumed in 15 days (3 films per day). Measurements of the volatile sulfur compound levels were performed using a halimeter in two stages: 1) before use and 2) 15 days after the first administration. Results showed a statistically significant reduction in volatile sulfur compound levels in 71.79% of the volunteers. We concluded that the compounded orodispersible films containing green tea and resveratrol demonstrated excellent results in reducing halitosis.

Related Keywords: Régis De Souza Apolinário, DMD, Maria Das Graças Afonso Miranda Chaves, DMD, PhD, Hanny Reis Mockdeci Gonçalves, DMD, MSc PhD (Candidate), Isadora Conde Ferreira Martins, DMD, Renée Mazilão De Paula, DMD, Ana Paula Alves Granato, DMD, Hudson Caetano Polonini, BPharm, PhD, Marcos Antônio Fernandes Brandão, BPharm, PhD, Anderson De Oliveira Ferreira, BPharm, PhD, Nádia Rezende Barbosa Raposo, BPharm, PhD, halitosis, bad breath, oral cavity, Camellia sinensis, green tea, polyphenols, resveratrol, oral polymer films, buccal strips, volatile sulfur compounds, orodispersible films, antimicrobial action, microbial load, bacterial infection

Related Categories: DENTAL, EAR NOSE THROAT, PEER-REVIEWED, DOSAGE FORMS/DRUG CARRIERS

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