Quantitation of Testosterone-Cypionate-in-Oil Injection using High Performance Liquid Chromatography
Author(s): Gupta Vishnu D, Pramar Y
Issue: Jul/Aug 1999 - Compounding Parenteral Products
View All Articles in Issue
Page(s): 314-315
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Abstract: A high-performance liquid chromatography assay method
for the quantitation of testosterone-cypionate-in-oil injection
has been developed. The assay method is very simple, accurate
and precise, with a percent relative standard deviation
of 1.2 based on five readings. The extraction procedure is
very simple compared with a very tedious and time-consuming
procedure given in the United States Pharmacopoeia/National
Formulary. The USP-NF assay method is based on gas
chromatography. The benzyl alcohol (preservative) did not interfere
with the assay procedure. The newly developed method
could not be applied to the quantitation of testosterone enanthate
since the results were consistently low (~87%). The average
recovery of testosterone cypionate from a commercial
dosage form was 98.7%.
Related Keywords:
gas chromatography, high-performance liquid chromatography, injection, testosterone cypionate
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