Stability of an Oral Liquid Dosage Form of Trovafloxacin Mesylate and Its Quantitation in Tablets Using High-Performance Liquid Chromatography
Author(s): Gupta Vishnu D
Issue: May/Jun 2000 - Compounding for the Ear, Nose and Throat
View All Articles in Issue
Page(s): 233-235
Download in electronic PDF format for $75
Abstract: A high-performance liquid chromatographic assay method for
the quantitation of trovafloxacin in film-coated tablets and an
oral liquid dosage form (10 mg/mL) prepared from tablets has
been developed. The assay method is very simple, precise and
accurate, with a percent relative standard deviation of 1.8 based
on five injections. The recovery from the tablets and the oral
liquid dosage form was very close to the label claims. The
method is stability indicating, since the peak from a degraded
sample (using sodium hydroxide) did not interfere with the assay
procedure. Furthermore, a number of excipients present in
the tablets and the oral liquid dosage form did not interfere with
the developed method. The oral liquid dosage form gave uniform
results and the drug was stable for at least 14 days when
stored in an amber-colored glass bottle at 25°C (± 1). The pH
of the formulation did not change.
Related Keywords:
acetonitrile, assay, degraded, fluoronaphthyridone, method, oral liquid
Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
Stability of an Oral Liquid Dosage Form of Trovafloxacin Mesylate and Its Quantitation in Tablets Using High-Performance Liquid Chromatography
Gupta Vishnu D
|
May/Jun 2000
Pg. 233-235
|
Quality-Control Analytical Methods: High-Performance Liquid Chromatography
Kupiec Thomas C
|
May/Jun 2004
Pg. 223-227
|
Quantitation of Testosterone-Cypionate-in-Oil Injection using High Performance Liquid Chromatography
Gupta Vishnu D, Pramar Y
|
Jul/Aug 1999
Pg. 314-315
|
Quantitation of Testosterone Propionate in an Injection Using High Performance Liquid Chromatography
Gupta Vishnu D
|
Mar/Apr 1999
Pg. 158-159
|
Quantitation of Testosterone in Suspension using High Performance Liquid Chromatography
Gupta Vishnu D
|
May/Jun 1999
Pg. 239-240
|
Stability of Oral Liquid Dosage Forms of Glycopyrrolate Prepared with the Use of Powder
Gupta Vishnu D
|
Sep/Oct 2003
Pg. 386-388
|
Chemical Stability of Isoniazid in an Oral Liquid Dosage Form
Gupta Vishnu D, Sood Arun
|
Mar/Apr 2005
Pg. 165-166
|
Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms
Gupta Vishnu D
|
Sep/Oct 2009
Pg. 445-446
|
Chemical Stability of Perphenazine in Two Commercially Available Vehicles for Oral Liquid Dosage Forms
Gupta Vishnu D
|
Jul/Aug 2008
Pg. 372-374
|
Trovafloxacin Mesylate 10-mg/mL Oral Liquid
Allen Loyd V Jr
|
May/Jun 2007
Pg. 251
|
Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents
Gupta Vishnu D
|
May/Jun 2007
Pg. 259-261
|
Chemical Stability of Perphenazine in Oral Liquid Dosage Forms
Gupta Vishnu D
|
Nov/Dec 2005
Pg. 484-486
|
Stability of an Oral Liquid Dosage Form of Glycopyrrolate Prepared from Tablets
Gupta Vishnu D
|
Nov/Dec 2001
Pg. 480-481
|
Chemical Stability of Brompheniramine Maleate in an Oral Liquid Dosage Form
Gupta Vishnu D, Gupta Vikas S
|
Jan/Feb 2011
Pg. 78-80
|
Development and Application of a High-Performance Liquid Chromatography Stability-Indicating Assay for Beyond-Use Date Determination of Compounded Topical Gels Containing Multiple Active Drugs
Gorman Gregory, Sokom Simara, Coward Lori, Arnold John J
|
Mar/Apr 2017
Pg. 164-170
|
Pediatric Compounding: Coloring Outside the Lines
Preckshot John
|
Jan/Feb 2001
Pg. 6-8
|
Stability of Acetyl-L-carnitine in 5% Dextrose Using a High-Performance Liquid Chromatography–Mass Spectrometry Times 2 Method
Zhang Yang, Jiang Hongliang, Hutson Paul
|
Mar/Apr 2012
Pg. 170-173
|
Long-term Stability of Zonisamide, Amitriptyline, and Glycopyrrolate in Extemporaneously Prepared Liquid-dosage Forms at Two Temperatures
Nahata Milap C
|
Mar/Apr 2016
Pg. 164-166
|
Physicochemical and Microbiological Stability of Amitriptyline Hydrochloride Oral Liquid Dosage Forms in PCCA Base, SuspendIt
Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
|
Jul/Aug 2022
Pg. 342-351
|
A New High-Performance Liquid Chromatographic Method for Fludarabine and Fludarabine Phosphate Compounded in Liposomes
Abang Anthony M, Abbas S Ali, Pham Trinh, Lambros Maria Polikandritou
|
Jul/Aug 2001
Pg. 320-322
|
Return to Top |