International Journal of Pharmaceutical Compounding

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Tonicity-Adjusting Agents, Featured Excipient:

Author(s): Allen Loyd V Jr

Issue: May/Jun 2000 - Compounding for the Ear, Nose and Throat
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Page(s): 218-220

Tonicity-Adjusting Agents, Featured Excipient: Page 1

Tonicity-Adjusting Agents, Featured Excipient: Page 2

Tonicity-Adjusting Agents, Featured Excipient: Page 3

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Abstract: The tonicity of solutions is a colligative property that depends primarily on the number of dissolved particles in solution. In this article, the author discusses the following United States Pharmacopeia/National Formulary tonicity-adjusting agents: Dextrose USP, Glycerin USP, Mannitol USP, Potassium Chloride USP, and Sodium Chloride USP. He also discusses compounding nasal solutions and ophthalmic solutions and provides a table listing physicochemical characteristics of the tonicity agents listed in the United States Pharmacopeia 24/National Formulary 19.

Related Keywords: boiling point, colligative properties, dextrose, freezing point, glycerin, hypertonic, hypotonic, iso-osmotic, isotonic, mannitol, nasal solutions, ophthalmic solutions, potassium, sodium chloride, tonicity, vapor pressure

Related Categories: EXCIPIENTS, SUPPORT

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