Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Basics: Excipients Used in Nonsterile Compounding, Part 4: Antioxidants and Chelating Agents

Author(s):  Allen Loyd V Jr

Issue:  Jan/Feb 2020 - Volume 24, Number 1
View All Articles in Issue

Abstract:  Pharmaceutical formulation involves patient acceptability and compliance, ease of preparation, microbiological considerations, and chemical and physical factors affecting compatibility of all ingredients and stability. Physical factors such as light, heat, and humidity can trigger or accelerate undesirable chemical reactions such as oxidation, hydrolysis, decarboxylation, racemization, and photolysis, compromising drug stability. Many drug products and preparations are subject to oxidation, which can often be catalyzed by light, temperature, hydrogen ion concentration, presence of trace metals, or peroxides. Oxidation of a product may be manifested as an unpleasant odor or taste, discoloration or other change in appearance, precipitation, or even a slight loss of activity. Antioxidants are often introduced to improve the shelf life of pharmaceuticals along with suggested procedures to minimize oxidation. Often, chelating agents are added with antioxidants to bind with any trace metals present and enhance the stability of the formulation.

Related Keywords: Loyd V. Allen, Jr., PhD, RPh, drug stability, oxidation, antioxidants, excipients, stabilizers, solubility, compounded sterile preparations, protein formulations, chelating agents, trace metals, chelates, buffering agents


Printer-Friendly Version

Download in electronic PDF format for $45

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Basics: Excipients Used in Nonsterile Compounding, Part 4: Antioxidants and Chelating Agents Allen Loyd V Jr Jan/Feb 2020 38-43 Buy
Wetting and/or Solubilizing Agents, Featured Excipient: Allen Loyd V Jr Jul/Aug 2001 310-312 Buy
Basics of Sterile Compounding: Excipients Used in Injections Akers Michael J Jul/Aug 2017 301-308 Buy
Formulation and Stability of Solutions Akers Michael J Mar/Apr 2016 137-141 Buy
Rapid-Dissolve Technology: An Interview With Loyd V. Allen, Jr., PhD, RPh Allen Loyd V Jr Nov/Dec 2003 449-450 Buy
Formulation and Stability of Solutions Akers Michael J Jan/Feb 2016 41-45 Buy
Compounding for the Effects of Weapons of Mass Destruction Sammarco Domenic A Jan/Feb 2003 10-15 View Sample
Basics of Compounding: Basics of Compounding with Complex Organic Molecules Allen Loyd V Jr May/Jun 2011 234-238 Buy
Intravenous Admixture Preparation Considerations, Part 7: Stability Issues Allen Loyd V Jr Nov/Dec 2020 473-478 Buy
Basics of Sterile Compounding: Manipulating Peptides and Proteins Akers Michael J May/Jun 2017 223-228 Buy