Stability of an Extemporaneously Formulated Levothyroxine Sodium Syrup Compounded from Commercial Tablets
Author(s): Alexander Kenneth S, Kothapalli Madhu R, Dollimor David
Issue: Jan/Feb 1997 - Hospice Care
View All Articles in Issue
Note: Electronic version includes errata or revisions.
Abstract: The stability of a 40-µg/mL extemporaneously formulated syrup from commercially available levothyroxine sodium tablets, using sorbitol 70% as the diluting vehicle, was studied. The concentration of levothyroxine sodium in the formulation was 40 µg/mL. The protocol included accelerated stability testing at temperatures of 40°, 50°, 60° and 70°C and a high-performance liquid chromatography assay procedure using testosterone propionate as the internal standard. The data were analyzed using an Arrhenius plot to determine the shelf-life of the formulation. The shelf-life was found to be approximately 15 days at 25°C and 47 days at 5°C.
Related Keywords: Synthroid
Related Categories: GERIATRICS, PEDIATRICS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES
Download in electronic PDF format for $65
| Related Articles from IJPC | ||||
| Title (Click for Abstract / Details) | Author | Issue | Page | View/Buy |
|---|---|---|---|---|
| Stability of an Extemporaneously Formulated Levothyroxine Sodium Syrup Compounded from Commercial Tablets | Alexander Kenneth S, Kothapalli Madhu R, Dollimor David | Jan/Feb 1997 | 60-63 | Buy |
| Stability of Levothyroxine Sodium Injection in Polypropylene Syringes | Gupta Vishnu D | Nov/Dec 2000 | 482-483 | Buy |