Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection

Gupta, Vishnu D; Bailey, RE

Abstract

Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection

Author(s): Gupta Vishnu D, Bailey RE

Issue: Jan/Feb 2000 - Compounding for Pain Management

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Page(s): 66-68

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Abstract

A high-performance liquid chromatographic assay method for the quantitation of alatrofloxacin in intravenous (IV) admixtures has been developed. The method is accurate and precise, with a percent relative standard deviation of 1.2% based on five injections. The method is stability indicating since the product of decomposition, trovafloxacin, did not interfere with the assay procedure. The IV admixtures of alatrofloxacin (1.88 mg/mL) in 5% dextrose and 0.45% sodium-chloride injections were stable for at least nine days when stored at room temperature. The pH values of the admixtures did not change and they remained clear throughout this study.

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