Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection

Gupta, Vishnu D; Bailey, RE

Author(s): Gupta Vishnu D, Bailey RE

Issue: Jan/Feb 2000 - Compounding for Pain Management
View All Articles in Issue

Page(s): 66-68

Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection Page 1

Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection Page 2

Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection Page 3

Download in electronic PDF format for $65

Abstract: A high-performance liquid chromatographic assay method for the quantitation of alatrofloxacin in intravenous (IV) admixtures has been developed. The method is accurate and precise, with a percent relative standard deviation of 1.2% based on five injections. The method is stability indicating since the product of decomposition, trovafloxacin, did not interfere with the assay procedure. The IV admixtures of alatrofloxacin (1.88 mg/mL) in 5% dextrose and 0.45% sodium-chloride injections were stable for at least nine days when stored at room temperature. The pH values of the admixtures did not change and they remained clear throughout this study.

Related Keywords: alatrofloxacin, dextrose, high performance liquid chromatography, injection, IV admixtures, pH, sodium chloride, stability, trovafloxacin

Related Categories: INFUSION, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version

Title/Author (Click for Abstract / Details / Purchase)	Issue/Page View/Buy
Related Articles from IJPC
Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection Gupta Vishnu D, Bailey RE	Jan/Feb 2000 Pg. 66-68
Quality-Control Analytical Methods: High-Performance Liquid Chromatography Kupiec Thomas C	May/Jun 2004 Pg. 223-227
Quantitation of Testosterone-Cypionate-in-Oil Injection using High Performance Liquid Chromatography Gupta Vishnu D, Pramar Y	Jul/Aug 1999 Pg. 314-315
Stability of an Oral Liquid Dosage Form of Trovafloxacin Mesylate and Its Quantitation in Tablets Using High-Performance Liquid Chromatography Gupta Vishnu D	May/Jun 2000 Pg. 233-235
Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Zhang Yan-ping, Trissel Lawrence A	Mar/Apr 1997 Pg. 132-134
Quantitation of Testosterone Propionate in an Injection Using High Performance Liquid Chromatography Gupta Vishnu D	Mar/Apr 1999 Pg. 158-159
Quantitation of Testosterone in Suspension using High Performance Liquid Chromatography Gupta Vishnu D	May/Jun 1999 Pg. 239-240
Stability of Cefepime Hydrochloride Dextrose in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Gupta Vishnu D, Maswoswe J, Bailey RE	Nov/Dec 1997 Pg. 435-436
Compatibility and Stability of Potassium Chloride and Magnesium Sulfate in 0.9% Sodium Chloride Injection and 5% Dextrose Injection Solutions Quay Irene, Tan Edward	Jul/Aug 2001 Pg. 323-324
Stability of Cefmetazole Sodium in 5% dextrose Injection and 0.9% Sodium Chloride Injection Gupta Vishnu D, Maswoswe J, Bailey RE	May/Jun 1997 Pg. 208-209