Stability of Ketamine Hydrochloride Injection After Reconstitution in Water for Injection and Storage in 1-mL Tuberculin Polypropylene Syringes for Pediatric Use
Author(s): Gupta Vishnu D
Issue: Jul/Aug 2002 - Compounding for BHRT and Legal and Regulatory Issues
View All Articles in Issue
Page(s): 316-317
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Abstract: The stability of ketamine hydrochloride (10 mg/mL) in water for injection stored
in polypropylene syringes has been studied at 25ºC by means of a stability-indicating
high-performance liquid chromatographic assay method. The concentrations
of the drug were directly related to peak heights, and the percent relative standard
deviation based on five injections was 1.9. The drug decomposed only when
the solution was boiled after sodium hydroxide was added. It did not decompose
in the presence of an acid or after 30 minutes of boiling. The injection did not
lose potency after 30 days of storage at 25ºC, and the pH value of 4.2 did not change.
Ketamine hydrochloride appears to be a very stable drug.
Related Keywords:
Ketamine hydrochloride injection, stability of after reconstitution
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