Stability of Ketamine Hydrochloride Injection After Reconstitution in Water for Injection and Storage in 1-mL Tuberculin Polypropylene Syringes for Pediatric Use

Gupta, Vishnu D

Abstract

Stability of Ketamine Hydrochloride Injection After Reconstitution in Water for Injection and Storage in 1-mL Tuberculin Polypropylene Syringes for Pediatric Use

Author(s): Gupta Vishnu D

Issue: Jul/Aug 2002 - Compounding for BHRT and Legal and Regulatory Issues

View All Articles in Issue

Page(s): 316-317

Download in electronic PDF format for $75

Abstract

The stability of ketamine hydrochloride (10 mg/mL) in water for injection stored in polypropylene syringes has been studied at 25ºC by means of a stability-indicating high-performance liquid chromatographic assay method. The concentrations of the drug were directly related to peak heights, and the percent relative standard deviation based on five injections was 1.9. The drug decomposed only when the solution was boiled after sodium hydroxide was added. It did not decompose in the presence of an acid or after 30 minutes of boiling. The injection did not lose potency after 30 days of storage at 25ºC, and the pH value of 4.2 did not change. Ketamine hydrochloride appears to be a very stable drug.

Related Keywords

Related Categories

Printer-Friendly Version

Related Articles from IJPC

Issue/Page View/Buy	Title/Author (Click for Abstract / Details / Purchase)
Jul/Aug 2002 Pg. 316-317	Stability of Ketamine Hydrochloride Injection After Reconstitution in Water for Injection and Storage in 1-mL Tuberculin Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D
Sep/Oct 2002 Pg. 388-390	Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes Author(s): Storms Meredith L, Stewart James T, Warren Flynn W
Mar/Apr 1997 Pg. 132-134	Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Author(s): Zhang Yan-ping, Trissel Lawrence A
Jan/Feb 2001 Pg. 75-77	Stability of Acyclovir Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D, Ling Jie
Jan/Feb 2001 Pg. 73-75	Stability of Ethacrynate Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D, Ling Jie
Jul/Aug 2003 Pg. 310-312	Chemical Stability of Cefuroxime Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D
Mar/Apr 2001 Pg. 151-152	Stability of Cefepime Hydrochloride After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D, Ling Jie
May/Jun 2011 Pg. 224-232	Quality Control Analytical Methods: Aqua Pura: Water Purification Systems and United States Pharmacopeia Waters for the Compounding Pharmacy, Part 2: USP Waters: Experts at the United States Pharmacopeia Answer Compounders' Questions Author(s): Schnatz Rick, Hernandex-Cardoso Antonio
May/Jun 2004 Pg. 228-230	Physical and Chemical Stability of Trepostinil Sodium Injection Packaged in Plastic Syringe Pump Reservoirs. Author(s): Xu Quanyun A, Trissel Lawrence A, Pham Lien
Sep/Oct 2019 Pg. 399-402	Sterile Basics: Pharmaceutical Waters Used in Sterile and Nonsterile Compounding Author(s): Allen Loyd V Jr
Mar/Apr 2004 Pg. 153-155	Chemical Stability of Phenylephrine HCl After Reconstitution in 0.9% Sodium Chloride Injection for Infusion Author(s): Gupta Vishnu D
May/Jun 2001 Pg. 230-231	Stability of Piperacillin Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D, Ling Jie
Jan/Feb 2003 Pg. 65-67	Stability of Glycopyrrolate Injection at Ambient Temperature and 4°C in Polypropylene Syringes Author(s): Storms Meredith L, Stewart James T, Warren Flynn W
Jan/Feb 2003 Pg. 68-70	Stability of Succinylcholine Chloride Injection at Ambient Temperature and 4 Degree C in Polypropylene Syringes Author(s): Storms Meredith L, Stewart James T, Warren Flynn W
Jul/Aug 2002 Pg. 308-310	Stability of Tubocurarine Chloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes Author(s): Stewart James T, Storms Meredith L, Warren Flynn W
Jul/Aug 2006 Pg. 318-319	Chemical Stability of Pyridoxine Hydrochloride 100-mg/mL Injection, Preservative Free Author(s): Gupta Vishnu D
Sep/Oct 2000 Pg. 396-397	Stability of Hydrocortisone Sodium Succinate After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D, Ling Jie
May/Jun 2002 Pg. 234-236	Stability of Cefotaxime Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D
Nov/Dec 2000 Pg. 480-481	Stability of Nafcillin Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D, Ling Jie
Nov/Dec 2010 Pg. 512	Amitriptyline Hydrochloride 2%, Baclofen 5%, Ketamine Hydrochloride 5%, Ketoprofen 10% in Pluronic Lecithin Organogel Author(s): Allen Loyd V Jr