Stability of Zidovudine and Dobutamine HCl Injections in 0.9% Sodium Chloride and 5% Dextrose Injections Stored at Ambient Temperature (23 ± 2°C) and 4°C in 50-mL Polyvinyl Chloride Bags Up to 24 Hours

Musami, Patrick; Stewart, James T; Taylor, E Will

Abstract

Stability of Zidovudine and Dobutamine HCl Injections in 0.9% Sodium Chloride and 5% Dextrose Injections Stored at Ambient Temperature (23 ± 2°C) and 4°C in 50-mL Polyvinyl Chloride Bags Up to 24 Hours

Author(s): Musami Patrick, Stewart James T, Taylor E Will

Issue: Jan/Feb 2004 - Androgen Deficiency in Women

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Page(s): 73-76

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Abstract

The stability of a 2-mg/mL zidovudine and 1-mg/mL dobutamine hydrochloride admixture stored in 0.9% sodium chloride and 5% dextrose injections in 50-mL polyvinyl chloride bags at ambient temperature (23 ± 2°C) and 4°C for up to 24 hours was studied. The samples were analyzed at 0, 4, 8 and 24 hours after preparation of the controls and known mixtures by means of a reverse-phase stability indicating high-performance liquid chromatographic method. The drug mixtures were stable for up to 24 hours, as shown by the greater than 90% of initial concentrations at the time of preparation. The pH of the drug solutions remained constant in the pH 6 to 7 range. These data support the stability of the zidovudine and dobutamine admixture under the storage conditions studied.

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