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Stability of Zidovudine and Dobutamine HCl Injections in 0.9% Sodium Chloride and 5% Dextrose Injections Stored at Ambient Temperature (23 ± 2°C) and 4°C in 50-mL Polyvinyl Chloride Bags Up to 24 Hours

Author(s):  Musami Patrick, Stewart James T, Taylor E Will

Issue:  Jan/Feb 2004 - Androgen Deficiency in Women
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Page(s):  73-76

Stability of Zidovudine and Dobutamine HCl Injections in 0.9% Sodium Chloride and 5% Dextrose Injections Stored at Ambient Temperature (23 ± 2°C) and 4°C in 50-mL Polyvinyl Chloride Bags Up to 24 Hours Page 1
Stability of Zidovudine and Dobutamine HCl Injections in 0.9% Sodium Chloride and 5% Dextrose Injections Stored at Ambient Temperature (23 ± 2°C) and 4°C in 50-mL Polyvinyl Chloride Bags Up to 24 Hours Page 2
Stability of Zidovudine and Dobutamine HCl Injections in 0.9% Sodium Chloride and 5% Dextrose Injections Stored at Ambient Temperature (23 ± 2°C) and 4°C in 50-mL Polyvinyl Chloride Bags Up to 24 Hours Page 3
Stability of Zidovudine and Dobutamine HCl Injections in 0.9% Sodium Chloride and 5% Dextrose Injections Stored at Ambient Temperature (23 ± 2°C) and 4°C in 50-mL Polyvinyl Chloride Bags Up to 24 Hours Page 4

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Abstract:  The stability of a 2-mg/mL zidovudine and 1-mg/mL dobutamine hydrochloride admixture stored in 0.9% sodium chloride and 5% dextrose injections in 50-mL polyvinyl chloride bags at ambient temperature (23 ± 2°C) and 4°C for up to 24 hours was studied. The samples were analyzed at 0, 4, 8 and 24 hours after preparation of the controls and known mixtures by means of a reverse-phase stability indicating high-performance liquid chromatographic method. The drug mixtures were stable for up to 24 hours, as shown by the greater than 90% of initial concentrations at the time of preparation. The pH of the drug solutions remained constant in the pH 6 to 7 range. These data support the stability of the zidovudine and dobutamine admixture under the storage conditions studied.

Related Keywords: Dobutamine hydrochloride and zidovudine injection, stability of, Musami, Patrick, MS, Stewart, James T, PhD, Taylor, E. Will, PhD, Zidovudine and dobutamine hydrochloride injection, stability of

Related Categories: INFUSION, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, STERILE PREPARATIONS

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