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Stability of Minoxidil in Espumil Foam Base

Author(s):  Geiger Christine M, Sorenson Bridget, Whaley Paul A

Issue:  Mar/Apr 2013 - Volume 17, Number 2
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Page(s):  165-167

Stability of Minoxidil in Espumil Foam Base Page 1
Stability of Minoxidil in Espumil Foam Base Page 2
Stability of Minoxidil in Espumil Foam Base Page 3

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Abstract:  Minoxidil is a drug used to stimulate hair growth and to slow balding. It is marketed under a number of trade names, including Rogaine, and is available in varying strength dose forms from a number of generic manufacturers. Minoxidil is available in oral and topical forms. In topical form, it can be applied by a metered-spray or a rub-on applicator. A hydroalcoholic compounding vehicle can minimize greasiness, itching, burning, and contact dermatitis where low concentrations of ethanol and propylene glycol are present. Espumil Foam base contains low concentrations of these ingredients and also can form a foam on topical application. Espumil’s unique delivery by foam-activating packaging assures simple application to difficult-to-treat areas, and it vanishes quickly after application, keeping it in place and avoiding healthy skin areas. The objective of this study was to determine the stability of minoxidil in Espumil Foam base. The studied sample was compounded into a 50-mg/ml solution and stored in a plastic foam- activating bottle at room temperature conditions. Three samples were assayed at each time point out to 90 days by a stability-indicating high-performance liquid chromatography method. The method was validated for its specificity through forced-degradation studies. The beyond-use date is at least 90 days, based on data collected when this formulation was stored at room temperature, protected from light.

Related Keywords: Christine M. Geiger, BS, Bridget Sorenson, BS, CAPM, Paul A. Whaley, BS, minoxidil, hair growth, baldness, excipients, stability


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