Abstract

Basic Principles of Lyophilization, Part 1

Author(s): Akers Michael J

Issue: Nov/Dec 2015 - Volume 19, Number 6

Page(s): 471-476

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  • Basic Principles of Lyophilization, Part 1 Page 2
  • Basic Principles of Lyophilization, Part 1 Page 3
  • Basic Principles of Lyophilization, Part 1 Page 4
  • Basic Principles of Lyophilization, Part 1 Page 5
  • Basic Principles of Lyophilization, Part 1 Page 6

Abstract

The achievement of a high-quality lyophilized (freezedried) dosage form involves the combination of optimal formulation design and optimal freeze-dry cycle design. This 2-part article describes how this can be done. Part 1 discusses the basic principles and procedures of lyophilization up to a discussion on the different stages of lyophilization. The stages of lyophilization are discussed in part 2.

Related Keywords

  • lyophilization
  • freezing-drying
  • freeze dried
  • freeze-dry cycle
  • parenteral drugs
  • biopharmaceuticals
  • stability
  • vacuum
  • volatile compounds
  • compounded sterile preparations
  • small molecules
  • large molecules
  • buffering agents
  • surface-active agents
  • competitive-binding agents
  • proteins
  • cyroprotectants
  • amino acids
  • polymers
  • polyols
  • sugars
  • polyethylene glycol
  • lyoprotectants

Related Categories

  • EXCIPIENTS
  • STABILITIES, COMPATIBILITIES
  • STORAGE

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