International Journal of Pharmaceutical Compounding

A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of all issues and individual articles published by the Journal since 1997.

LEARN MORE

Basics of Compounding: Hot Melt Extrusion

Author(s): DePasquale Seth

Issue: Nov/Dec 2017 - Volume 21, Number 6
View All Articles in Issue

Page(s): 471-479

Basics of Compounding: Hot Melt Extrusion Page 1

Basics of Compounding: Hot Melt Extrusion Page 2

Basics of Compounding: Hot Melt Extrusion Page 3

Basics of Compounding: Hot Melt Extrusion Page 4

Basics of Compounding: Hot Melt Extrusion Page 5

Basics of Compounding: Hot Melt Extrusion Page 6

Basics of Compounding: Hot Melt Extrusion Page 7

Basics of Compounding: Hot Melt Extrusion Page 8

Basics of Compounding: Hot Melt Extrusion Page 9

Download in electronic PDF format for $75

Abstract: Hot Melt Extrusion, a production process that has been around for quite some time, has the ability to produce innovative compounds not previously achievable with conventional methods. However, many variables need to be considered prior to production. The use of small-scale extruders and 3D printers provides compounders a pathway for developing new dosage forms at a minimal cost while initial research is being completed. This article discusses the uses of Hot Melt Extrusion, the equipment used, the current and future applications, and the challenges with the technology.

Related Keywords: hot melt extrusion method, drug polymer combinations, extruders, stability, plasticizers, excipients, active pharmaceutical ingredients, solubility, taste masking, targeted drug delivery, implants, sustained release preparations

Related Categories: EXCIPIENTS, TECHNOLOGY, QUALITY CONTROL, DOSAGE FORMS/DRUG CARRIERS

Printer-Friendly Version

Title/Author (Click for Abstract / Details / Purchase)	Issue/Page View/Buy
Related Articles from IJPC
Basics of Compounding: Hot Melt Extrusion DePasquale Seth	Nov/Dec 2017 Pg. 471-479
Featured Excipient: Plasticizers Allen Loyd V Jr	Mar/Apr 2003 Pg. 145-148
Basics of Compounding: Excipients Used in Nonsterile Compounding, Part 11: Drug Tastes: Innate, Induced, and Improved Allen Loyd V Jr	Sep/Oct 2021 Pg. 396-400
Basics of Compounding–Nonsterile: Compounding Self-emulsifying Drug Delivery Systems and Other Self-emulsifying Lipid Formulations, Part 1 Allen Loyd V Jr	May/Jun 2018 Pg. 220-228
Orodispersible Films for Compounding Pharmacies Ferreira Anderson O, Brandão Marcos Antônio F, Raposo Francisco José, Polonini Hudson C, Raposo Nádia Rezende Barbosa	Nov/Dec 2017 Pg. 454-461
Basics of Sterile Compounding: Excipients Used in Injections Akers Michael J	Jul/Aug 2017 Pg. 301-308
Taste Masking Study of Cocoa Butter Fast Melt Tablet (FMT) Formulations Containing Memantine Hydrochloride Liew Kai Bin, Chew Yik Ling, Uddin ABM Helal, Lee Siew-Keah, Lakshminarayanan Vijayakumar, Janakiraman Ashok Kumar, Khalid Syed Haroon, Ramanunny Arya Kadukkattil, Xia Yang	Nov/Dec 2024 Pg. 502-508
Personalized Medicine and Customized Drug Delivery Systems: The New Trend of Drug Delivery and Disease Management Soni Abhishek, Gowthamarajan Kuppusamy, Radhakrishnan Arun	Mar/Apr 2018 Pg. 108-121
Basics of Compounding--Nonsterile: Compounding Self-emulsifying Drug Delivery Systems and Other Self-emulsifying Lipid Formulations, Part 2 Allen Loyd V Jr	Jul/Aug 2018 Pg. 294-300
Basics of Compounding: Compounding Films Allen Loyd V Jr	Jul/Aug 2016 Pg. 298-305
Compatibility of Active Pharmaceutical Ingredients Combinations Compounded in Cleoderm™, a Cream Base for Personalized Dermatological Treatments Marianni Bruna, Silva Carolina Costa Vicente, Polonini Hudson	Mar/Apr 2025 Pg. 150-162
Basics of Compounding: Excipients Used in Nonsterile Compounding, Part 10: Rectal Suppository Bases Allen Loyd V Jr	Jul/Aug 2021 Pg. 304-309
Basics of Sterile Compounding: Biopharmaceutics of Injectable Dosage Forms Akers Michael J	Jan/Feb 2017 Pg. 47-56
Stability Assessment of 10 Active Pharmaceutical Ingredients Compounded in SyrSpend SF Geiger Christine M, Sorenson Bridget, Whaley Paul	Sep/Oct 2015 Pg. 420-427
Basics of Compounding: Basics of Compounding with Potency Designated Ingredients Allen Loyd V Jr	Jan/Feb 2011 Pg. 56-61
Quality Control: Personal Protective Equipment for Use When Handling Hazardous Drugs Dillon L R	Jan/Feb 2020 Pg. 30-36
Nonsterile Basics of Compounding: Using U.S. Food and Drug Administration-approved Commercial Products as Ingredients Allen Loyd V Jr	Nov/Dec 2023 Pg. 474-481
Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives Trimble John O, Light Bob	Nov/Dec 2017 Pg. 530-535
Biotechnology, Nanotechnology, and Pharmacogenomics and Pharmaceutical Compounding, Part 2 Allen Loyd V	Jul/Aug 2015 Pg. 280-287
Drug Shortage Compounding: The Only Safe Medication Source in a Time of Crisis Lyon Joanna	Nov/Dec 2012 Pg. 456-460
Return to Top