Abstract

Basics of Compounding: Hot Melt Extrusion

Author(s): DePasquale Seth

Issue: Nov/Dec 2017 - Volume 21, Number 6

Page(s): 471-479

Download in electronic PDF format for $75
  • Basics of Compounding: Hot Melt Extrusion Page 1
  • Basics of Compounding: Hot Melt Extrusion Page 2
  • Basics of Compounding: Hot Melt Extrusion Page 3
  • Basics of Compounding: Hot Melt Extrusion Page 4
  • Basics of Compounding: Hot Melt Extrusion Page 5
  • Basics of Compounding: Hot Melt Extrusion Page 6
  • Basics of Compounding: Hot Melt Extrusion Page 7
  • Basics of Compounding: Hot Melt Extrusion Page 8
  • Basics of Compounding: Hot Melt Extrusion Page 9

Abstract

Hot Melt Extrusion, a production process that has been around for quite some time, has the ability to produce innovative compounds not previously achievable with conventional methods. However, many variables need to be considered prior to production. The use of small-scale extruders and 3D printers provides compounders a pathway for developing new dosage forms at a minimal cost while initial research is being completed. This article discusses the uses of Hot Melt Extrusion, the equipment used, the current and future applications, and the challenges with the technology.

Related Keywords

  • hot melt extrusion method
  • drug polymer combinations
  • extruders
  • stability
  • plasticizers
  • excipients
  • active pharmaceutical ingredients
  • solubility
  • taste masking
  • targeted drug delivery
  • implants
  • sustained release preparations

Related Categories

  • EXCIPIENTS
  • TECHNOLOGY
  • QUALITY CONTROL
  • DOSAGE FORMS/DRUG CARRIERS

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
Nov/Dec 2017
Pg. 471-479
Basics of Compounding: Hot Melt Extrusion
Author(s): DePasquale Seth
Mar/Apr 2003
Pg. 145-148
Featured Excipient: Plasticizers
Author(s): Allen Loyd V Jr
Sep/Oct 2021
Pg. 396-400
Basics of Compounding: Excipients Used in Nonsterile Compounding, Part 11: Drug Tastes: Innate, Induced, and Improved
Author(s): Allen Loyd V Jr
May/Jun 2018
Pg. 220-228
Basics of Compounding–Nonsterile: Compounding Self-emulsifying Drug Delivery Systems and Other Self-emulsifying Lipid Formulations, Part 1
Author(s): Allen Loyd V Jr
Nov/Dec 2017
Pg. 454-461
Orodispersible Films for Compounding Pharmacies
Author(s): Ferreira Anderson O, Brandão Marcos Antônio F, Raposo Francisco José, Polonini Hudson C, Raposo Nádia Rezende Barbosa
Jul/Aug 2017
Pg. 301-308
Basics of Sterile Compounding: Excipients Used in Injections
Author(s): Akers Michael J
Nov/Dec 2024
Pg. 502-508
Taste Masking Study of Cocoa Butter Fast Melt Tablet (FMT) Formulations Containing Memantine Hydrochloride
Author(s): Liew Kai Bin, Chew Yik Ling, Uddin ABM Helal, Lee Siew-Keah, Lakshminarayanan Vijayakumar, Janakiraman Ashok Kumar, Khalid Syed Haroon, Ramanunny Arya Kadukkattil, Xia Yang
Mar/Apr 2018
Pg. 108-121
Personalized Medicine and Customized Drug Delivery Systems: The New Trend of Drug Delivery and Disease Management
Author(s): Soni Abhishek, Gowthamarajan Kuppusamy, Radhakrishnan Arun
Jul/Aug 2018
Pg. 294-300
Basics of Compounding--Nonsterile: Compounding Self-emulsifying Drug Delivery Systems and Other Self-emulsifying Lipid Formulations, Part 2
Author(s): Allen Loyd V Jr
Jul/Aug 2016
Pg. 298-305
Basics of Compounding: Compounding Films
Author(s): Allen Loyd V Jr
Mar/Apr 2025
Pg. 150-162
Compatibility of Active Pharmaceutical Ingredients Combinations Compounded in Cleoderm™, a Cream Base for Personalized Dermatological Treatments
Author(s): Marianni Bruna, Silva Carolina Costa Vicente, Polonini Hudson
Jul/Aug 2021
Pg. 304-309
Basics of Compounding: Excipients Used in Nonsterile Compounding, Part 10: Rectal Suppository Bases
Author(s): Allen Loyd V Jr
Jan/Feb 2017
Pg. 47-56
Basics of Sterile Compounding: Biopharmaceutics of Injectable Dosage Forms
Author(s): Akers Michael J
Sep/Oct 2015
Pg. 420-427
Stability Assessment of 10 Active Pharmaceutical Ingredients Compounded in SyrSpend SF
Author(s): Geiger Christine M, Sorenson Bridget, Whaley Paul
Jan/Feb 2011
Pg. 56-61
Basics of Compounding: Basics of Compounding with Potency Designated Ingredients
Author(s): Allen Loyd V Jr
Jan/Feb 2020
Pg. 30-36
Quality Control: Personal Protective Equipment for Use When Handling Hazardous Drugs
Author(s): Dillon L R
Nov/Dec 2023
Pg. 474-481
Nonsterile Basics of Compounding: Using U.S. Food and Drug Administration-approved Commercial Products as Ingredients
Author(s): Allen Loyd V Jr
Nov/Dec 2017
Pg. 530-535
Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives
Author(s): Trimble John O, Light Bob
Jul/Aug 2015
Pg. 280-287
Biotechnology, Nanotechnology, and Pharmacogenomics and Pharmaceutical Compounding, Part 2
Author(s): Allen Loyd V
Nov/Dec 2012
Pg. 456-460
Drug Shortage Compounding: The Only Safe Medication Source in a Time of Crisis
Author(s): Lyon Joanna