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Basics: Excipients Used in Nonsterile Compounding, Part 3: Preservatives

Author(s):  Allen Loyd V Jr

Issue:  Nov/Dec 2019 - Volume 23, Number 6
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Abstract:  Preservative selection is a critical step in the preparation of a formulation to ensure its microbiological effectiveness and stability. A number of physicochemical factors must be considered when selecting a preservative, including concentration, solubility, and pH. A preservative must also be nontoxic, stable, compatible, inexpensive, and have an acceptable taste, odor, and color. It should also be effective against a wide variety of bacteria, fungi, and yeasts, and be free from incompatibilities. This article discusses some of the factors involved in selecting an appropriate preservative.

Related Keywords: Loyd V. Allen, Jr., PhD, RPh, nonsterile compounding, preservatives, microbial contaminants, drug contamination, drug incompatibility, alcohol, microorganisms, dosage forms, compatibility, interactions

Related Categories: EXCIPIENTS, STABILITIES, COMPATIBILITIES, QUALITY CONTROL, DOSAGE FORMS/DRUG CARRIERS

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