Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Author(s): Storms Meredith L, Stewart James T, Warren Flynn W
Issue: Sep/Oct 2002 - Veterinary Compounding
View All Articles in Issue
Page(s): 388-390
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Abstract: The stability of 20 mg/mL lidocaine hydrochloride injection
in 12-mL polypropylene syringes stored at ambient temperature
and at 4°C for up to 90 days was investigated. A highperformance
liquid chromatographic stability-indicating
assay was used to determine the concentration level of lidocaine
hydrochloride injection at 0, 1, 4, 7, 15, 30, 45, 60,
and 90 days after preparation of the syringes. Methylparaben,
which was added as a preservative, did not interfere with the
assay. The injections in plastic syringes were stable for up to
90 days at both ambient temperature and at 4°C. The pH of
lidocaine hydrochloride injection did not change appreciably
during the 90-day study period. These data indicate the stability
of lidocaine hydrochloride under the storage conditions
investigated in this study.
Related Keywords:
Lidocaine hydrochloride injection, effect of temperature on stability of, Lidocaine hydrochloride injection, stability of during storage
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