In Vitro Transdermal Diffusion of Zileuton from a Topical Gel

Bigeleisen, Paul E

Abstract

In Vitro Transdermal Diffusion of Zileuton from a Topical Gel

Author(s): Bigeleisen Paul E

Issue: Sep/Oct 2006 - Dermatology

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Page(s): 392-395

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Abstract

Zileuton, a leukotriene inhibitor used to treat asthma, is usually administered via the oral route. A transdermal drug delivery system for zileuton was developed for this study. A vertical diffusion cell and freshly harvested human skin were used to test the system. Thirteen percent (3.3 mg) of the drug was delivered into the dermis within 24 hours, and 13.6% (3.3 mg) of the drug was delivered through the epidermis into the receiving chamber of the diffusion cell within 24 hours. A specially constructed transdermal zileuton gel delivered 13.1% (3.3 mg) of the drug through the epidermis into the receiving chamber within 24 hours. These results are predictive of the successful use of zileuton as a transdermal gel in human subjects.

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