Abstract

Chemical Penetration Enhancers

Author(s): Newton Stephen J

Issue: Sep/Oct 2013 - Volume 17, Number 5

Page(s): 370-374

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Abstract

Chemical penetration enhancers are utilized in topical preparations as a method for enhancing permeation of drugs across the skin. In particular, they are utilized for transdermal delivery of medications in an attempt to produce a systemic response, to avoid first-pass metabolism, and to decrease the gastrointestinal transit time observed with oral medications. A review of the selection of chemical penetration enhancers, their mechanism of action, the most common chemical penetration enhancers in each class, and alternatives will be discussed in detail.

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