Abstract

Chemical Penetration Enhancers

Author(s): Newton Stephen J

Issue: Sep/Oct 2013 - Volume 17, Number 5

Page(s): 370-374

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Abstract

Chemical penetration enhancers are utilized in topical preparations as a method for enhancing permeation of drugs across the skin. In particular, they are utilized for transdermal delivery of medications in an attempt to produce a systemic response, to avoid first-pass metabolism, and to decrease the gastrointestinal transit time observed with oral medications. A review of the selection of chemical penetration enhancers, their mechanism of action, the most common chemical penetration enhancers in each class, and alternatives will be discussed in detail.

Related Keywords

  • topical preparation
  • transdermal penetration
  • dermal administration
  • skin
  • cutaneous absorption
  • ethanol
  • isopropyl myristate
  • oleic acid
  • emu oil
  • azone
  • propylene glycol
  • decyl methyl sulfoxide
  • NDMS
  • dimethyl sulfoxide
  • DMSO
  • limonene
  • urea
  • carbamide
  • water
  • dimethylformamide
  • DMF
  • pyrrolidones
  • NMP
  • soft enhancement of percutaneous absorption
  • SEPA

Related Categories

  • EXCIPIENTS
  • DOSAGE FORMS/DRUG CARRIERS

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