Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Chemical Penetration Enhancers

Author(s):  Newton Stephen J

Issue:  Sep/Oct 2013 - Volume 17, Number 5
View All Articles in Issue

Abstract:  Chemical penetration enhancers are utilized in topical preparations as a method for enhancing permeation of drugs across the skin. In particular, they are utilized for transdermal delivery of medications in an attempt to produce a systemic response, to avoid first-pass metabolism, and to decrease the gastrointestinal transit time observed with oral medications. A review of the selection of chemical penetration enhancers, their mechanism of action, the most common chemical penetration enhancers in each class, and alternatives will be discussed in detail.

Related Keywords: Stephen J. Newton, RPh, topical preparation, transdermal penetration, dermal administration, skin, cutaneous absorption, ethanol, isopropyl myristate, oleic acid, emu oil, azone, propylene glycol, decyl methyl sulfoxide, NDMS, dimethyl sulfoxide, DMSO, limonene, urea, carbamide, water, dimethylformamide, DMF, pyrrolidones, NMP, soft enhancement of percutaneous absorption, SEPA


Printer-Friendly Version

Download in electronic PDF format for $55

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Chemical Penetration Enhancers Newton Stephen J Sep/Oct 2013 370-374 Buy
Veterinary Transdermal Medications: A to Z Davidson Gigi S Mar/Apr 2003 106-113 Buy
Ketoconazole 2%, Terbenafine 1%, Acetic Acid 2%, and Urea 2% in Dimethyl Sulfoxide Nail Polish Allen Loyd V Jr Mar/Apr 2022 142 Buy
Idoxuridine 15% in Dimethyl Sulfoxide (DMSO) Allen Loyd V Jr May/Jun 2001 208 Buy
Enhancement of Skin Penetration of Nonsteroidal Anti-Inflammatory Drugs from Extemporaneously Compounded Topical-Gel Formulations Goodwin Donald A, Fuhram L Clifton Nov/Dec 1999 496-500 Buy
Profile of a Practice: Stephen J. Newton, RPh, and PharmaTech Services, Inc., Avon, Colo. Allen Loyd V Jr Mar/Apr 2004 107-109 Buy
Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives Trimble John O, Light Bob Nov/Dec 2017 530-535 Buy
Gabapentin in Elastic Liposomes: Preparation, Characterization, Drug Release, and Penetration Through Porcine Skin Le Uyen Minh, Baltzley Sarah, AlGhananeem Abeer Nov/Dec 2018 498-503 Buy
In Vitro Skin Penetration and Skin Content of Progesterone from Various Topical Formulations Heustess Allie, Asbill Scott, Eagerton David, Arnold John Nov/Dec 2014 512-515 Buy
A Need for Propylene Glycol-Free Ascorbic Acid Oral Liquid McElhiney Linda F Nov/Dec 2004 458-460 Buy