Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Basics of Compounding: Compounding with Microneedle Arrays, Part 1: Introduction and Overview

Author(s):  Allen Loyd V Jr

Issue:  Sep/Oct 2022 - Volume 26, Number 5
View All Articles in Issue

Page(s):  400-408

Basics of Compounding: Compounding with Microneedle Arrays, Part 1: Introduction and Overview Page 1
Basics of Compounding: Compounding with Microneedle Arrays, Part 1: Introduction and Overview Page 2
Basics of Compounding: Compounding with Microneedle Arrays, Part 1: Introduction and Overview Page 3
Basics of Compounding: Compounding with Microneedle Arrays, Part 1: Introduction and Overview Page 4
Basics of Compounding: Compounding with Microneedle Arrays, Part 1: Introduction and Overview Page 5
Basics of Compounding: Compounding with Microneedle Arrays, Part 1: Introduction and Overview Page 6
Basics of Compounding: Compounding with Microneedle Arrays, Part 1: Introduction and Overview Page 7
Basics of Compounding: Compounding with Microneedle Arrays, Part 1: Introduction and Overview Page 8
Basics of Compounding: Compounding with Microneedle Arrays, Part 1: Introduction and Overview Page 9

Download in electronic PDF format for $65

Abstract:  Over the years, numerous approaches have been used to increase drug penetration of the skin. Transdermal drug delivery has potential advantages over other conventional routes of drug delivery, as it can provide a non- invasive and painless alternative to parenteral routes. Also, the pharmacokinetic profiles of drugs can be more uniform with less variability, resulting in improved patient compliance. Classical topical formulations are different from those intended for transdermal drug delivery, as they are generally applied to broken, diseased, or damaged skin, whereas, transdermal drugs are applied to healthy skin. On the negative side, the use of transdermal drug delivery is limited by the restrictions inherent in the lipophilic stratum corneum barrier, which allows a limited number of drug molecules with certain physicochemical properties to be delivered. This article, which represents part 1 of a series of articles on compounding with microneedles, provides an introduction and overview of this topic.

Related Keywords: Loyd V. Allen Jr., PhD, RPh, drug penetration, transdermal drug delivery, lipophilic stratum corneum layer, skin permeability, microneedle array, percutaneous absorption, dermis layer, systemic absorption, drug solubility, passive drug diffusion, partition coefficient, melting point, penetration enhancement technology, chemical penetration enhancers, lipophilicity, iontophoresis, electroporation, sonophoresis, molecular weight, pharmacokinetics, formulations, minoxidil, ketamine hydrochloride, ketoprofen

Related Categories: DERMATOLOGY, FORMULATIONS, TECHNOLOGY

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Advanced Compounding: Compounding with Microneedle Arrays, Part 3: Microneedle Array Development in the Literature and Quality Control of Microneedle Arrays
Allen Loyd V Jr
Jan/Feb 2023
Pg. 30-37

Basics of Compounding: Compounding with Microneedle Arrays, Part 1: Introduction and Overview
Allen Loyd V Jr
Sep/Oct 2022
Pg. 400-408

Compounding with Microneedle Arrays, Part 2: Preparation and Administration Methods
Allen Loyd V Jr
Nov/Dec 2022
Pg. 490-495

Veterinary Transdermal Medications: A to Z
Davidson Gigi S
Mar/Apr 2003
Pg. 106-113

Rapid-Dissolve Technology: An Interview With Loyd V. Allen, Jr., PhD, RPh
Allen Loyd V Jr
Nov/Dec 2003
Pg. 449-450

Transdermals: The Skin as Part of a Drug Delivery System
Allen Loyd V Jr
Jul/Aug 2011
Pg. 308-315

Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives
Trimble John
, Light Bob
May/Jun 2016
Pg. 250-256

Compounding in the Pharmacy Curriculum: Beyond the Basics
Hinkle Amanda R
, Newton Gail D
May/Jun 2004
Pg. 181-185

Basics of Compounding for Dry-Skin Conditions
Allen Loyd V Jr
Nov/Dec 2003
Pg. 460-463

View Sample
Basics of Compounding: Compounding Nonsterile Preparations Using Cyclodextrins
Allen Loyd V Jr
Mar/Apr 2022
Pg. 118-126

Basics of Compounding for Hazardous Drugs, Part 1: An Introduction
Allen Loyd V Jr
Sep/Oct 2006
Pg. 377-379

Basics of Compounding–Nonsterile: Compounding Self-emulsifying Drug Delivery Systems and Other Self-emulsifying Lipid Formulations, Part 1
Allen Loyd V Jr
May/Jun 2018
Pg. 220-228

Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives
Trimble John O
, Light Bob
Nov/Dec 2017
Pg. 530-535

In Vitro Skin Penetration and Skin Content of Progesterone from Various Topical Formulations
Heustess Allie
, Asbill Scott, Eagerton David, Arnold John
Nov/Dec 2014
Pg. 512-515

Gabapentin in Elastic Liposomes: Preparation, Characterization, Drug Release, and Penetration Through Porcine Skin
Le Uyen Minh
, Baltzley Sarah, AlGhananeem Abeer
Nov/Dec 2018
Pg. 498-503

Basics of Compounding: Excipients Used in Nonsterile Compounding, Part 11: Drug Tastes: Innate, Induced, and Improved
Allen Loyd V Jr
Sep/Oct 2021
Pg. 396-400

Feline Transdermal Formulation Considerations
Forsythe Lauren Eichstadt
Nov/Dec 2017
Pg. 446-452

Current Topical Treatments in Wound Healing - Part 1
Helmke Christopher D
Jul/Aug 2004
Pg. 269-274

PreScription: 2017 Pharmacy Compounding Issues: The U.S. Food and Drug Administration, Harzardous Drugs, and Wasted Drugs
Allen Loyd V Jr
Sep/Oct 2017
Pg. 356

The Use of Pluronic Lecithin Organogels in the Transdermal Delivery of Drugs
Bramwell Bethany L
, Williams LaVonn A
Jan/Feb 2012
Pg. 62-63