Abstract

Nonsterile Basics of Compounding: Compounding with Antioxidants, Part 1: An Overview

Author(s): Allen Loyd V Jr

Issue: Jul/Aug 2023 - Volume 27, Number 4

Page(s): 295-302

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  • Nonsterile Basics of Compounding: Compounding with Antioxidants, Part 1: An Overview Page 7
  • Nonsterile Basics of Compounding: Compounding with Antioxidants, Part 1: An Overview Page 8

Abstract

This article, which is part 1 of a series on compounding with antioxidants, discusses specific preparation methods and techniques along with packaging, storing, and labeling issues. Also presented are the allowable overages from the United States Pharmacopeia’s discussion on “Commercial Parenteral Products”. Some considerations related to potential issues when compounding with commercial products are also discussed using specific examples. The article ends with a discussion of product standardization and look-alike products. The formulation of an antioxidant system is accomplished primarily through trial and error. With some experimentation and patience, a suitable, stable system with the required characteristics can be obtained.

Related Keywords

  • antioxidants
  • oxidation
  • cell damage
  • chemical stability
  • physical stability
  • shelf life
  • drug degradation
  • drug deterioration
  • pH
  • temperature
  • solvents
  • light
  • oxygen
  • carbon dioxide
  • moisture
  • particle size
  • drug instability
  • polymorphs
  • crystallization
  • vaporization
  • adsorption
  • storage containers
  • packaging materials
  • chelating agents

Related Categories

  • EXCIPIENTS
  • STABILITIES, COMPATIBILITIES
  • ALTERNATIVE/COMPLEMENTARY THERAPIES

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