Stability of Zidovudine and Ranitidine in 0.9% sodium Chloride and 5% Dextrose Injections Stored at Ambient Temperature (23 ± 2°C) and 4°C in 50-mL Polyvinylchloride Bags Up to 24 Hours.
Author(s): Musami Patrick, Stewart James T, Taylor E Will
Issue: May/Jun 2004 - Andropause
View All Articles in Issue
Page(s): 236-239
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Abstract: The stability of a 2-mg/mL zidovudine and 0.5-mg/mL
ranitidine admixture stored in 0.9% sodium chloride and
5% dextrose injections in 50-mL polyvinylchloride bags at
ambient temperature and 4°C up to 24 hours was studied.
The samples were analyzed at 0, 4, 8 and 24 hours after
preparation of the controls and admixtures by means of a
reverse-phase, stability-indicating, high-performance liquid
chromatographic method. The drug mixtures were stable
for up to 24 hours, showing levels of greater than 90%
of the initial drug concentrations at the time of preparation.
The pH of the admixtures was in the pH 5–6 range.
These data support the stability of the zidovudine and ranitidine
admixture under the storage conditions studied.
Related Keywords:
Musami, Patrick, MS, Stewart, James T., PhD, Taylor, E. Will, PhD, Ranitidine and zidovudine admixture, stability of, Zidovudine and ranitidine admixture, stability of
Related Categories:
INFUSION, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, STERILE PREPARATIONS
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