Stability of Succinylcholine Chloride Injection at Ambient Temperature and 4 Degree C in Polypropylene Syringes

Storms, Meredith L; Stewart, James T; Warren, Flynn W

Abstract

Stability of Succinylcholine Chloride Injection at Ambient Temperature and 4 Degree C in Polypropylene Syringes

Author(s): Storms Meredith L, Stewart James T, Warren Flynn W

Issue: Jan/Feb 2003 - Terrorism

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Page(s): 68-70

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Abstract

The stability of 20-mg/mL succinylcholine chloride injection in 12-mL polypropylene syringes stored at ambient temperature and 4°C for up to 90 days was investigated. Concentration levels of succinylcholine chloride injection were determined at 0, 1, 4, 7, 15, 30, 45, 60, and 90 days after preparation of the syringes by means of a high-performance liquid chromatographic stability-indicating assay. Methylparaben, which was added as a preservative, did not interfere with the assay. The loss in potency was less than 10% after 45 days of storage at 25°C and less than 1% after 90 days of storage at 4°C. The pH of succinylcholine chloride injection did not change appreciably during the 90-day study period.

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