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Considerations for Percutaneous Absorption

Author(s):  Newton Stephen J, Cook Jennifer M

Issue:  Jul/Aug 2010 - Sterile Compounding
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Abstract:  Percutaneous absorption is affected by numerous factors. Whether they are internal or external factors, the compounding pharmacist must collectively consider these variables in order to provide a safe and effective topical preparation for the patient. By considering the physiochemical and dermal factors that affect percutaneous absorption of a medication, an effective topical medication can be formulated to treat the patient’s specific indication. Furthermore, this article will review the background information necessary to formulate transdermal prescriptions for their patients.

Related Keywords: Stephen J. Newton, RPh, Jennifer M. Cook, PharmD, percutaneous absorption, topical preparations, transdermal administration, skin hydration, skin damage, dermal lipids, pluronic solubility, formulation, solid lipid nanoparticles, particle size, partition coefficient

Related Categories: DERMATOLOGY, EXCIPIENTS, FORMULATIONS, DOSAGE FORMS/DRUG CARRIERS

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