Stability of Tubocurarine Chloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes

Stewart, James T; Storms, Meredith L; Warren, Flynn W

A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

LEARN MORE

Stability of Tubocurarine Chloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes

Author(s): Stewart James T, Storms Meredith L, Warren Flynn W,

Issue: Jul/Aug 2002 - Compounding for BHRT and Legal and Regulatory Issues
View All Articles in Issue

Page(s): 308-310

Stability of Tubocurarine Chloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes Page 1

Stability of Tubocurarine Chloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes Page 2

Stability of Tubocurarine Chloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes Page 3

Download in electronic PDF format for $65

Abstract: The stability of 3 mg/mL tubocurarine chloride (Figure 1) injection in 3-mL polypropylene syringes stored at ambient temperature and at 4ºC for up to 90 days was investigated. A high-performance liquid chromatographic stability- indicating assay was used to determine concentration levels of tubocurarine chloride injection 0, 1, 4, 7, 15, 30, 45, 60, and 90 days after preparation of the syringes. Benzyl alcohol, which was used as a preservative, did not interfere with the assay. At 25ºC, the loss in potency was less than 10% after the syringes had been stored for 45 days; at 4ºC, that loss was less than 1% after 90 days of storage. The pH of tubocurarine chloride injection did not change appreciably during the 90- day study period.

Related Keywords: Tubocurarine chloride injection, stability of

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version

Title/Author (Click for Abstract / Details / Purchase)	Issue/Page View/Buy
Related Articles from IJPC
Stability of Tubocurarine Chloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes Stewart James T, Storms Meredith L, Warren Flynn W	Jul/Aug 2002 Pg. 308-310
Compatibility and Stability of Potassium Chloride and Magnesium Sulfate in 0.9% Sodium Chloride Injection and 5% Dextrose Injection Solutions Quay Irene, Tan Edward	Jul/Aug 2001 Pg. 323-324
Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Zhang Yan-ping, Trissel Lawrence A	Mar/Apr 1997 Pg. 132-134
Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection Gupta Vishnu D, Bailey RE	Jan/Feb 2000 Pg. 66-68
Stability of Succinylcholine Chloride Injection at Ambient Temperature and 4 Degree C in Polypropylene Syringes Storms Meredith L, Stewart James T, Warren Flynn W	Jan/Feb 2003 Pg. 68-70
Stability of Dexmedetomidine in Polyvinyl Chloride Bags Containing 0.9% Sodium Chloride Intended for Subcutaneous Infusions Wolfe Amanda, Zhang Jeremy, Lapenskie Julie, Downar James, Kanji Salmaan	Jul/Aug 2021 Pg. 330-335
Stability of Alprostadil in 0.9% Sodium Chloride Stored in Polyvinyl Chloride Containers McCluskey Susan V, Kirkham Kylian, Munson Jessica M	Mar/Apr 2017 Pg. 150-153
Stability of Milrinone Lactate 200 mcg/mL in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Wong Frances, Gill Mark A	Mar/Apr 1998 Pg. 168-169
Stability of Ketorolac Tromethamine in 5% Dextrose Injection and 0.9% Sodium Chloride Injections Gupta Vishnu D, Maswoswe J, Bailey RE	May/Jun 1997 Pg. 206-207
Stability of Cefmetazole Sodium in 5% dextrose Injection and 0.9% Sodium Chloride Injection Gupta Vishnu D, Maswoswe J, Bailey RE	May/Jun 1997 Pg. 208-209

Particle Measuring Systems - USP <797> Environmental Monitoring Solutions